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Split-bolus computed tomography urography (CTU) achieves more than half of radiation dose reduction in females and overweight patients than conventional single-bolus computed tomography urography
Translational Oncology ( IF 4.5 ) Pub Date : 2021-06-08 , DOI: 10.1016/j.tranon.2021.101151
Li-Jen Wang , Yon-Cheong Wong , Yi-Shuan Hwang , See-Tong Pang , Cheng-Keng Chuang , Ying-Hsu Chang

Objective

To compare radiation dose between single-bolus and split-bolus computed tomography urography (CTU).

Materials and methods

We prospectively enrolled patients undergoing single-bolus and split-bolus CTU from 2019 June to 2020 June. The age, sex and body mass index (BMI) of each patient was recorded and categorized into BMI classes. The radiation dose indices including volumetric computed dose index, size-specific dose estimate, dose length product and effective dose of each patient were compared between 2 CTU groups with calculation of dose reduction proportions (DRPs).

Results

Seventy-six patients underwent single-bolus (n = 39) and split-bolus (n = 37) CTU. Single-bolus CTU had higher radiation doses than split-bolus CTU and there were statistically significant differences of all radiation dose indices between two CTU groups without and with stratification by sex and BMI classes. The DRPs of volumetric computed dose index, size-specific dose estimate, dose length product and effective dose using split-bolus CTU were 49%, 49%. 50%, and 45%, respectively. Multiple linear regression with an effect size (f2) as 2.24 showed females (p = 0.027) and higher BMI classes (p = 2.38 *10−9) were associated with higher effective doses; and split-bolus CTU, lower effective doses (p = 5.40 *10−15). Using split-bolus CTU, females had consistently higher DRP of all radiation dose indices than males (54–55% versus 40–42%). Overweight patients had the largest DRP as 55% of effective dose.

Conclusions

Split-bolus CTU could be preferred by its significant radiation dose reduction effect in regard to single-bolus CTU, which was most profound in females and overweight patients.



中文翻译:


与传统单次团注计算机断层尿路造影 (CTU) 相比,分次团注计算机断层尿路造影 (CTU) 可将女性和超重患者的辐射剂量减少一半以上


 客观的


比较单次推注和分次推注计算机断层尿路造影 (CTU) 的辐射剂量。

 材料和方法


我们前瞻性地招募了 2019 年 6 月至 2020 年 6 月期间接受单次推注和分次推注 CTU 的患者。记录每位患者的年龄、性别和体重指数 (BMI),并将其分为 BMI 类别。比较2个CTU组之间的辐射剂量指数,包括体积计算剂量指数、尺寸特定剂量估计、剂量长度乘积和每位患者的有效剂量,并计算剂量减少比例(DRP)。

 结果


76 名患者接受了单次推注 ( n = 39) 和分次推注 ( n = 37) CTU。单次推注 CTU 的辐射剂量高于分次推注 CTU,并且在未按性别和 BMI 类别分层和分层的情况下,两个 CTU 组之间的所有辐射剂量指数均存在统计学显着差异。使用分次推注 CTU 计算的体积计算剂量指数、尺寸特异性剂量估计、剂量长度乘积和有效剂量的 DRP 分别为 49%、49%。分别为 50% 和 45%。效应大小(f 2 )为 2.24 的多元线性回归显示,女性 ( p = 0.027) 和较高的 BMI 类别 ( p = 2.38 *10 -9 ) 与较高的有效剂量相关;和分次推注 CTU,有效剂量较低( p = 5.40 *10 -15 )。使用分次推注 CTU,女性所有辐射剂量指数的 DRP 始终高于男性(54-55% 对比 40-42%)。超重患者的最大DRP为有效剂量的55%。

 结论


与单次推注 CTU 相比,分次推注 CTU 因其显着的辐射剂量降低效果而受到青睐,这对于女性和超重患者影响最为深远。

更新日期:2021-06-08
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