Novel Diabetic Foot Wound Dressing Based on Multifunctional Hydrogels with Extensive Temperature-Tolerant, Durable, Adhesive, and Intrinsic Antibacterial Properties,ACS Applied Materials & Interfaces

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Novel Diabetic Foot Wound Dressing Based on Multifunctional Hydrogels with Extensive Temperature-Tolerant, Durable, Adhesive, and Intrinsic Antibacterial Properties
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2021-06-07 , DOI: 10.1021/acsami.1c05514
Hou Liu ₁ , Zuhao Li ₂ , Yue Zhao ₁ , Yubin Feng ₁ , Andrei V Zvyagin _{3,

4} , Jincheng Wang ₂ , Xiaoyu Yang ₂ , Bai Yang ₁ , Quan Lin ₁

Affiliation

Diabetic foot ulcers (DFUs) are hard-healing chronic wounds and susceptible to bacterial infection. Conventional hydrogel dressings easily lose water at high temperature or freeze at low temperature, making them unsuitable for long-term use or in extreme environments. Herein, a temperature-tolerant (−20 to 60 °C) antibacterial hydrogel dressing is fabricated by the assembly of polyacrylamide, gelatin, and ε-polylysine. Owing to the water/glycerin (Gly) binary solvent system, the resultant hydrogel (G-PAGL) displayed good heat resistance and antifreezing properties. Within the wide temperature range (−20 to 60 °C), all the desirable features of the hydrogel, including superstretchability (>1400%), enduring water retention, adhesiveness, and persistent antibacterial property, are quite stable. Remarkably, the hydrogel wound dressing displayed lasting and broad antibacterial activity against Gram-positive and Gram-negative bacteria. Satisfactorily, the double-network (DN) G-PAGL hydrogel dressing could effectively promote the healing of DFUs by accelerating collagen deposition, promoting angiogenesis, and inhibiting bacterial breed. As far as we know, this is the first time that the extensive temperature-tolerant DN hydrogel with antibacterial ability is developed to use as DFU wound dressing. The G-PAGL hydrogel provides more choices for DFU wound dressings that could be used in extreme environments.

中文翻译：

基于多功能水凝胶的新型糖尿病足伤口敷料具有广泛的耐温性、耐用性、粘性和内在抗菌特性

糖尿病足溃疡 (DFU) 是难以愈合的慢性伤口，容易受到细菌感染。传统的水凝胶敷料在高温下容易失水或在低温下结冰，不适合长期使用或在极端环境下使用。在此，由聚丙烯酰胺、明胶和 ε-聚赖氨酸组装而成的耐高温（-20 至 60°C）抗菌水凝胶敷料。由于水/甘油（Gly）二元溶剂体系，所得水凝胶（G-PAGL）显示出良好的耐热性和防冻性能。在较宽的温度范围内（-20 至 60 °C），水凝胶的所有理想特性，包括超拉伸性（> 1400%）、持久保水性、粘附性和持久抗菌性能，都非常稳定。值得注意的是，水凝胶伤口敷料对革兰氏阳性菌和革兰氏阴性菌显示出持久而广泛的抗菌活性。令人满意的是，双网络 (DN) G-PAGL 水凝胶敷料可以通过加速胶原沉积、促进血管生成和抑制细菌繁殖来有效促进 DFU 的愈合。据我们所知，这是第一次开发出具有抗菌能力的广泛耐温DN水凝胶用作DFU伤口敷料。G-PAGL 水凝胶为可用于极端环境的 DFU 伤口敷料提供了更多选择。促进血管生成，抑制细菌繁殖。据我们所知，这是第一次开发出具有抗菌能力的广泛耐温DN水凝胶用作DFU伤口敷料。G-PAGL 水凝胶为可用于极端环境的 DFU 伤口敷料提供了更多选择。促进血管生成，抑制细菌繁殖。据我们所知，这是第一次开发出具有抗菌能力的广泛耐温DN水凝胶用作DFU伤口敷料。G-PAGL 水凝胶为可用于极端环境的 DFU 伤口敷料提供了更多选择。

更新日期：2021-06-16

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