Various pharmaceuticals have been detected in natural water and wastewater bodies, causing threats to water ecosystem and human health. Although electrochemical anodic-oxidation (EAO) has been shown to be efficient for pharmaceuticals degradation from aqueous solution, it still has a distinct need to apply EAO technology for pharmaceuticals removal rationally. This review provides the most recent progress on the mechanisms, influencing factors, and new technique of EAO for pharmaceuticals degradation. The mechanism and superiority of EAO were analyzed. Major influencing factors (e.g., electrode materials, electrochemical reactor, applied current density, anode-cathode distance, electrolyte type and concentration, initial solution pH value, and initial pharmaceuticals concentration) were discussed on the removal of pharmaceuticals. The latest development of reactive electrochemical membranes (REM) was regarded as an emerging EAO technique, and it was also highlighted. This work revealed that the EAO of pharmaceuticals has extraordinary application prospects in the field of water and wastewater treatment.