Expanding the ZIFs Repertoire for Biological Applications with the Targeted Synthesis of ZIF-20 Nanoparticles,ACS Applied Materials & Interfaces

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Expanding the ZIFs Repertoire for Biological Applications with the Targeted Synthesis of ZIF-20 Nanoparticles
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2021-06-04 , DOI: 10.1021/acsami.1c05657
Jacob I Deneff ₁ , Kimberly S Butler ₂ , Paul G Kotula ₃ , Braden E Rue ₂ , Dorina F Sava Gallis ₁

Affiliation

Owing to their facile synthesis, tailorable porosity, diverse compositions, and low toxicity, zeolitic imidazolate framework (ZIF) nanoparticles (NPs) have emerged as attractive platforms for a variety of biologically relevant applications. To date, a small subset of ZIFs representing only two topologies and very few linker chemistries have been studied in this realm. We seek to expand the bio-design space for ZIF NPs through the targeted synthesis of a hierarchically complex ZIF based on two types of cages, ZIF-20, with lta topology. This study demonstrates the rapid synthesis and size tunability of ZIF-20 particles across the micro and nanoregimes via microwave heating and the use of a modulating agent. To evaluate the utility of ZIF particles for biological applications, we examine their stability in biologically relevant media and demonstrate biocompatibility with A549 human epithelial cells. Further, the ability to encapsulate and release methylene blue, a therapeutic and bioimaging agent, is validated. Importantly, ZIF-20 NPs display a unique behavior relative to previously studied ZIFs based on their specific structural and chemical features. This finding highlights the need to expand the design space across the broader ZIFs family, to exploit a wider range of relevant properties for biological applications and beyond.

中文翻译：

通过 ZIF-20 纳米颗粒的靶向合成扩展 ZIF 的生物应用库

由于其易于合成、可定制的孔隙率、多样化的组成和低毒性，沸石咪唑酯骨架 (ZIF) 纳米粒子 (NPs) 已成为各种生物相关应用的有吸引力的平台。迄今为止，该领域仅研究了一小部分 ZIF，仅代表两种拓扑结构和很少的接头化学。我们寻求通过基于两种类型的笼子 ZIF-20 和lta的分层复杂 ZIF 的靶向合成来扩展 ZIF NPs 的生物设计空间拓扑。这项研究证明了通过微波加热和使用调节剂，ZIF-20 颗粒在微米和纳米结构中的快速合成和尺寸可调。为了评估 ZIF 颗粒在生物应用中的效用，我们检查了它们在生物相关培养基中的稳定性，并证明了与 A549 人类上皮细胞的生物相容性。此外，还验证了封装和释放亚甲蓝（一种治疗剂和生物成像剂）的能力。重要的是，基于 ZIF-20 NPs 的特定结构和化学特征，相对于先前研究的 ZIFs，ZIF-20 NPs 显示出独特的行为。这一发现凸显了在更广泛的 ZIF 家族中扩展设计空间的必要性，以利用更广泛的生物应用及其他领域的相关特性。

更新日期：2021-06-16

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