Natural Products and Bioprospecting ( IF 4.8 ) Pub Date : 2021-06-05 , DOI: 10.1007/s13659-021-00315-y Bei-Bei Gao 1 , Yu-Fei Ou 1, 2 , Qin-Feng Zhu 3 , Zhi-Ping Zhou 1, 2 , Zhen-Tao Deng 1, 2 , Meng Li 1, 2 , Qin-Shi Zhao 1
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Three new clerodane-type diterpene glycosides, (5R,6S,8R,9S,10R)-6-O-[β-d-glucopyranosyl-(1 → 4)-α-l-rhamnopyranosyl]cleroda-3,13(16),14-diene (1), (5R,6S,8R,9S,10R,13S)-6-O-[β-d-glucopyranosyl-(1 → 4)-α-l-rhamnopyranosyl]-2-ox-oneocleroda-3,13-dien-15-ol (2), (5R,6S,8R,9S,10R)-6-O-[β-d-glucopyranosyl-(1 → 4)-α-l-rhamnopyranosyl]-(13E)-2-oxoneocleroda-3,14-dien-13-ol (3), together with two known compounds 4 and 5 were isolated from Dicranopteris pedata. The structures of these compounds were elucidated by detailed spectroscopic analysis, and the absolute configuration of compound 2 was determined by ECD calculations. In addition, compound 1 exhibited weak inhibitory activities against SMMC-7721, MCF-7 and SW480.
Graphic Abstract
中文翻译：
芒萁中的Clerodane型二萜糖苷
三个新的Clerodane型二萜糖苷，(5 R ,6 S ,8 R ,9 S ,10 R )-6- O -[ β - d -glucopyranosyl-(1 → 4)- α - l -rhamnopyranosyl]cleroda- 3,13(16),14-二烯 ( 1 ), (5 R ,6 S ,8 R ,9 S ,10 R ,13 S )-6- O -[ β- d -吡喃葡萄糖基-(1 → 4) - α - L -吡喃鼠李糖基]-2-ox-oneocleroda-3,13-dien-15-ol ( 2 ), (5 R ,6 S ,8 R ,9 S ,10 R )-6- O -[ β分离出- d -吡喃葡萄糖基-(1 → 4)- α - l -吡喃鼠李糖基]-(13 E )-2-oxoneocleroda-3,14-dien-13-ol ( 3 ) 以及两种已知化合物4和5来自芒萁。通过详细的光谱分析阐明了这些化合物的结构，并通过 ECD 计算确定了化合物2的绝对构型。此外，化合物1对SMMC-7721、MCF-7和SW480表现出弱抑制活性。
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