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Molecular Engineering of High-Performance Aggregation-Induced Emission Photosensitizers to Boost Cancer Theranostics Mediated by Acid-Triggered Nucleus-Targeted Nanovectors
ACS Nano ( IF 15.8 ) Pub Date : 2021-06-02 , DOI: 10.1021/acsnano.1c03700 Zhijun Zhang 1, 2 , Wenhan Xu 3 , Peihong Xiao 1, 2 , Miaomiao Kang 1, 2 , Dingyuan Yan 1, 2 , Haifei Wen 1 , Nan Song 1, 2 , Dong Wang 1 , Ben Zhong Tang 3
ACS Nano ( IF 15.8 ) Pub Date : 2021-06-02 , DOI: 10.1021/acsnano.1c03700 Zhijun Zhang 1, 2 , Wenhan Xu 3 , Peihong Xiao 1, 2 , Miaomiao Kang 1, 2 , Dingyuan Yan 1, 2 , Haifei Wen 1 , Nan Song 1, 2 , Dong Wang 1 , Ben Zhong Tang 3
Affiliation
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Phototheranostics involving both fluorescence imaging and photodynamic therapy has been recognized to be potentially powerful for cancer treatment by virtue of various intrinsic advantages. However, the state-of-the-art materials in this area are still far from ideal toward practical applications, ascribed to their respective and collective drawbacks, such as inefficient imaging quality, inferior reactive oxygen species (ROS) production, the lack of subcellular-targeting capability, and dissatisfactory delivery. In this paper, these shortcomings are successfully addressed through the integration of finely engineered photosensitizers with aggregation-induced emission (AIE) features and well tailored nanocarrier systems. The yielded AIE NPs simultaneously exhibit broad absorption in the visible-light region, bright near-infrared fluorescence emission, high ROS generation, as well as tumor lysosomal acidity-activated and nucleus-targeted delivery functions, making them promising for precise and efficient phototheranostics. Both in vitro and in vivo evaluations show that the presented nanotheranostic systems bearing good photostability and appreciable biosecurity perform well in fluorescence imaging-guided photodynamic cancer therapy. This study thus not only extends the application scopes of AIE nanomaterials but also offers useful insights into constructing advanced cancer phototheranostics.
中文翻译：
高性能聚集诱导发射光敏剂的分子工程促进酸触发核靶向纳米载体介导的癌症治疗
由于各种内在优势，涉及荧光成像和光动力疗法的光热疗法已被认为对癌症治疗具有潜在的强大作用。然而，该领域最先进的材料仍远非理想的实际应用，这归因于它们各自和集体的缺点，例如低效的成像质量、较差的活性氧 (ROS) 产生、缺乏亚细胞- 瞄准能力和不满意的交付。在本文中，通过将精细设计的光敏剂与聚集诱导发射 (AIE) 特征和精心定制的纳米载体系统相结合，成功解决了这些缺点。产生的 AIE NPs 同时在可见光区域表现出广泛的吸收，明亮的近红外荧光发射、高 ROS 生成以及肿瘤溶酶体酸度激活和细胞核靶向递送功能，使它们有望用于精确和高效的光疗。两个都体外和体内评估表明，所提出的纳米治疗系统具有良好的光稳定性和可观的生物安全性，在荧光成像引导的光动力癌症治疗中表现良好。因此，这项研究不仅扩展了 AIE 纳米材料的应用范围，而且还为构建先进的癌症光疗提供了有用的见解。
更新日期：2021-06-22
中文翻译：
高性能聚集诱导发射光敏剂的分子工程促进酸触发核靶向纳米载体介导的癌症治疗
由于各种内在优势，涉及荧光成像和光动力疗法的光热疗法已被认为对癌症治疗具有潜在的强大作用。然而，该领域最先进的材料仍远非理想的实际应用，这归因于它们各自和集体的缺点，例如低效的成像质量、较差的活性氧 (ROS) 产生、缺乏亚细胞- 瞄准能力和不满意的交付。在本文中，通过将精细设计的光敏剂与聚集诱导发射 (AIE) 特征和精心定制的纳米载体系统相结合，成功解决了这些缺点。产生的 AIE NPs 同时在可见光区域表现出广泛的吸收，明亮的近红外荧光发射、高 ROS 生成以及肿瘤溶酶体酸度激活和细胞核靶向递送功能，使它们有望用于精确和高效的光疗。两个都体外和体内评估表明，所提出的纳米治疗系统具有良好的光稳定性和可观的生物安全性，在荧光成像引导的光动力癌症治疗中表现良好。因此，这项研究不仅扩展了 AIE 纳米材料的应用范围，而且还为构建先进的癌症光疗提供了有用的见解。
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