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Recent Progress in Detection and Profiling of Cancer Cell-Derived Exosomes
Small ( IF 13.0 ) Pub Date : 2021-06-02 , DOI: 10.1002/smll.202007971 Huiwen Xiong 1 , Zhipeng Huang 1 , Zhejun Yang 1 , Qiuyuan Lin 1 , Bin Yang 1 , Xueen Fang 1 , Baohong Liu 1 , Hui Chen 1 , Jilie Kong 1
Small ( IF 13.0 ) Pub Date : 2021-06-02 , DOI: 10.1002/smll.202007971 Huiwen Xiong 1 , Zhipeng Huang 1 , Zhejun Yang 1 , Qiuyuan Lin 1 , Bin Yang 1 , Xueen Fang 1 , Baohong Liu 1 , Hui Chen 1 , Jilie Kong 1
Affiliation
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Exosomes, known as nanometer-sized vesicles (30–200 nm), are secreted by many types of cells. Cancer-derived exosomes have great potential to be biomarkers for early clinical diagnosis and evaluation of cancer therapeutic efficacy. Conventional detection methods are limited to low sensitivity and reproducibility. There are hundreds of papers published with different detection methods in recent years to address these challenges. Therefore, in this review, pioneering researches about various detection strategies are comprehensively summarized and the analytical performance of these tests is evaluated. Furthermore, the exosome molecular composition (protein and nucleic acid) profiling, a single exosome profiling, and their application in clinical cancer diagnosis are reviewed. Finally, the principles and applications of machine learning method in exosomes researches are presented.
中文翻译：
癌细胞来源的外泌体检测和分析的最新进展
外泌体，被称为纳米级囊泡（30-200 nm），由多种细胞分泌。癌症衍生的外泌体具有成为早期临床诊断和评估癌症治疗效果的生物标志物的巨大潜力。传统的检测方法受限于低灵敏度和可重复性。近年来，有数百篇论文发表了不同的检测方法来解决这些挑战。因此，在这篇综述中，对各种检测策略的开创性研究进行了全面总结，并对这些测试的分析性能进行了评估。此外，还综述了外泌体分子组成（蛋白质和核酸）分析、单一外泌体分析及其在临床癌症诊断中的应用。最后，
更新日期：2021-06-02
中文翻译：
癌细胞来源的外泌体检测和分析的最新进展
外泌体，被称为纳米级囊泡（30-200 nm），由多种细胞分泌。癌症衍生的外泌体具有成为早期临床诊断和评估癌症治疗效果的生物标志物的巨大潜力。传统的检测方法受限于低灵敏度和可重复性。近年来，有数百篇论文发表了不同的检测方法来解决这些挑战。因此，在这篇综述中，对各种检测策略的开创性研究进行了全面总结，并对这些测试的分析性能进行了评估。此外，还综述了外泌体分子组成（蛋白质和核酸）分析、单一外泌体分析及其在临床癌症诊断中的应用。最后，
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