Fluorenylmethyloxycarbonyl (Fmoc)-conjugated amino acids, especially Fmoc-phenylalanine (Fmoc-F), are promising antibacterial agents with self-assembly capabilities. However, they possess weak antibacterial activities against gram-negative bacteria, which restricts their wide range of biomedical applications. In this study, Fmoc-F-based self-assembled supramolecular hydrogels were fabricated through a facile incorporation of silver ions. The prepared supramolecular hydrogels showed antibacterial properties (>98.0%) against both Staphylococcus aureus (S. aureus, gram-positive) and Escherichia coli (E. coli, gram-negative) bacteria. Moreover, the hydrogels were biocompatible, and the cell viability against mouse fibroblast cells was more than 85.0%. These results indicate that the Fmoc-F@Ag hydrogel can be used effectively for antibacterial applications.

芴甲氧羰基 (Fmoc)-共轭氨基酸，尤其是 Fmoc-苯丙氨酸 (Fmoc-F)，是具有自组装能力的有前途的抗菌剂。然而，它们对革兰氏阴性菌的抗菌活性较弱，限制了其广泛的生物医学应用。在这项研究中，通过轻松掺入银离子制备了基于 Fmoc-F 的自组装超分子水凝胶。制备的超分子水凝胶对金黄色葡萄球菌（金黄色葡萄球菌，革兰氏阳性）和大肠杆菌（大肠杆菌，革兰氏阴性）细菌。此外，水凝胶具有生物相容性，对小鼠成纤维细胞的细胞活力超过 85.0%。这些结果表明 Fmoc-F@Ag 水凝胶可以有效地用于抗菌应用。