Biodegradable magnesium alloys have excellent properties with respect to biodegradability, biocompatibility, and biomechanics, which may indicate a possibility of its application in intestinal stents. Investigation of Mg-Zn-Y-Nd alloy's application in intestinal stents has been performed. This study aims to investigate the degradation behavior of Mg-Zn-Y-Nd alloy intestinal stents coated with poly(L-lactide)/paclitaxel in the intestinal environment and its biocompatibility with intestinal tissue. In this paper, Mg-Zn-Y-Nd alloy's corrosion properties were evaluated by the immersion test in human feces, SEM and XRD, and animal tests. In vitro results showed that when the Mg-Zn-Y-Nd alloy was immersed in human feces for two weeks, its corrosion resistance could be improved by micro arc oxidation (MAO) and poly-l-lactide (PLLA) dual coating. Additionally, this result was also confirmed in vivo experiments by rabbit model. And animal tests also demonstrated that the Mg-Zn-Y-Nd alloy with MAO/PLLA/paclitaxel dual coating drug-eluting stents could inhibit the proliferation of local intestinal tissue around the stents. However, in vivo studies illustrated that the intestinal stents gradually degraded in rabbit model within 12 days. Considering the degradation rate of the stent was faster than expected in rabbits, the support performance of the scaffold requires further improvement.

可生物降解镁合金在生物降解性、生物相容性和生物力学方面具有优异的性能，这可能表明其在肠道支架中的应用可能性。研究了Mg-Zn-Y-Nd合金在肠支架中的应用。本研究旨在探讨涂有聚L-丙交酯/紫杉醇的Mg-Zn-Y-Nd合金肠支架在肠道环境中的降解行为及其与肠道组织的生物相容性。本文通过人体粪便浸泡试验、SEM和XRD以及动物试验对Mg-Zn-Y-Nd合金的腐蚀性能进行了评价。体外实验结果表明，Mg-Zn-Y-Nd合金在人体粪便中浸泡两周后，通过微弧氧化（MAO）和聚乳酸（PLLA）双重涂层可以提高其耐腐蚀性。此外，这一结果也在兔模型的体内实验中得到证实。并且动物试验也表明，具有MAO/PLLA/紫杉醇双涂层药物洗脱支架的Mg-Zn-Y-Nd合金能够抑制支架周围局部肠组织的增殖。然而，体内研究表明，在兔模型中肠支架在 12 天内逐渐降解。考虑到支架在兔体内的降解速度快于预期，支架的支撑性能需要进一步提高。体内研究表明，在兔模型中肠支架在 12 天内逐渐降解。考虑到支架在兔体内的降解速度快于预期，支架的支撑性能需要进一步提高。体内研究表明，在兔模型中肠支架在 12 天内逐渐降解。考虑到支架在兔体内的降解速度快于预期，支架的支撑性能需要进一步提高。