Acta Biomaterialia ( IF 9.4 ) Pub Date : 2021-05-31 , DOI: 10.1016/j.actbio.2021.05.031 Li Liu 1 , Xianxian Liang 2 , Xiangxian Xu 3 , Xiang Zhang 2 , Jun Wen 1 , Kun Chen 4 , Xiaodan Su 4 , Zhaogang Teng 5 , Guangming Lu 1 , Jian Xu 6
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Transcatheter arterial chemoembolization (TACE) is the main treatment for liver cancer. Although many embolic agents have been exploited in TACE, embolic agents combining embolization, drug loading, and imaging properties have not yet been constructed. Herein, we report a new magnetic mesoporous embolic microsphere that can simultaneously be loaded with doxorubicin (Dox), block vessels, and be observed by magnetic resonance imaging (MRI). The microspheres were prepared by decorating magnetic polystyrene/Fe3O4 particles with mesoporous organosilica microparticles (denoted as PS/Fe3O4@MONs). The PS/Fe3O4@MONs were uniformly spherical and large (50 µm), with a high specific surface area, uniform mesopores, and a Dox loading capacity of 460.8 µg mg−1. Dox-loaded PS/Fe3O4@MONs (PS/Fe3O4@MON@Dox) effectively inhibited liver cancer cell growth. A VX2 rabbit liver tumor model was constructed to study the efficacy of TACE with PS/Fe3O4@MON@Dox. In vivo, PS/Fe3O4@MON@Dox could be smoothly delivered through an arterial catheter to achieve chemoembolization. Moreover, PS/Fe3O4@MON@Dox and residual tumor parenchyma could be distinguished on MRI, which is of great significance for evaluating the efficacy of TACE. Histopathology showed that PS/Fe3O4@MON@Dox could be deposited in the tumor vessels, completely blocking the blood supply. Overall, PS/Fe3O4@MON@Dox showed good drug loading, embolization and imaging performance as well as potential for use in TACE.
Statement of Significance
Transcatheter arterial chemoembolization (TACE) is the main treatment for liver cancer. Although many embolic agents have been exploited in TACE, embolic agents combining embolization, drug-loading, and imaging properties have not yet been constructed. In this work, we prepared magnetic mesoporous microspheres as a new embolic agent that can simultaneously load doxorubicin (Dox), block blood vessels and enable magnetic resonance imaging. Overall, this new embolic microsphere-mediated TACE strategy for liver cancer showed good therapeutic effects, and the PS/Fe3O4@MON@Dox embolic microspheres provide a new avenue for improving the efficacy of TACE for liver cancer and postoperative evaluation.
中文翻译：
磁性介孔栓塞微球在肝癌经导管动脉化疗栓塞术中的应用
经导管动脉化疗栓塞术（TACE）是肝癌的主要治疗方法。尽管在 TACE 中已经开发了许多栓塞剂，但尚未构建结合栓塞、载药和成像特性的栓塞剂。在此，我们报告了一种新的磁性介孔栓塞微球，它可以同时装载阿霉素 (Dox)、阻断血管并通过磁共振成像 (MRI) 进行观察。通过用介孔有机二氧化硅微粒（表示为 PS/Fe 3 O 4 @MONs）装饰磁性聚苯乙烯/Fe 3 O 4颗粒来制备微球。PS/Fe 3 O 4@MON 是均匀的球形和大 (50 µm)，具有高比表面积、均匀的中孔和 460.8 µg mg -1的 Dox 负载能力。负载 Dox 的 PS/Fe 3 O 4 @MONs (PS/Fe 3 O 4 @MON@Dox) 有效抑制肝癌细胞生长。构建 VX2 兔肝肿瘤模型以研究 TACE 与 PS/Fe 3 O 4 @MON@Dox的疗效。在体内，PS/Fe 3 O 4 @MON@Dox 可以通过动脉导管顺利输送以实现化学栓塞。此外，PS/Fe 3 O 4@MON@Dox 和残留的肿瘤实质在 MRI 上可以区分，这对评估 TACE 的疗效具有重要意义。组织病理学表明，PS/Fe 3 O 4 @MON@Dox 可以沉积在肿瘤血管中，完全阻断血液供应。总体而言，PS/Fe 3 O 4 @MON@Dox 显示出良好的载药量、栓塞和成像性能以及用于 TACE 的潜力。
重要性声明
经导管动脉化疗栓塞术（TACE）是肝癌的主要治疗方法。尽管已经在 TACE 中开发了许多栓塞剂，但尚未构建结合栓塞、载药和成像特性的栓塞剂。在这项工作中，我们制备了磁性介孔微球作为一种新的栓塞剂，可以同时加载阿霉素 (Dox)、阻断血管并实现磁共振成像。总体而言，这种新的栓塞微球介导的肝癌 TACE 策略显示出良好的治疗效果，PS/Fe 3 O 4 @MON@Dox 栓塞微球为提高 TACE 对肝癌的疗效和术后评估提供了新的途径。
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