Palladium-Catalyzed Allenamide Carbopalladation/Allylation with Active Methine Compounds,Organic Letters

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Palladium-Catalyzed Allenamide Carbopalladation/Allylation with Active Methine Compounds
Organic Letters ( IF 4.9 ) Pub Date : 2021-05-28 , DOI: 10.1021/acs.orglett.1c01369
Xiaoyi Zhu ₁ , Ruibo Li ₁ , Hequan Yao ₁ , Aijun Lin ₁

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A palladium-catalyzed allenamide carbopalladation/allylation with active methine compounds has been developed. Various indoles and isoquinolinones bearing a quaternary carbon center were achieved with good efficiency, a broad substrate scope and good functional group tolerance. This reaction underwent cascade oxidative addition, carbopalladation, and allylic alkylation, and two new C–C bonds were formed in one pot.

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