The emergence of the biomimetic nano-drug delivery system provides a feasible way for the clinical treatment of cancer. Noble metal nanomaterials often possess unique and intriguing physicochemical properties, optical properties, electromagnetic properties and catalytic properties, therefore have broad applications in the field of biomedicine. In this work, the porous Au@Pt bimetallic nanoparticles were synthesized via the blending of the chloroauric acid (a gold precursor) with the potassium chloroplatinate (a platinum precursor) at the ratio of 1:1. These Au@Pt NPs exhibited decent catalytic properties, high drug loading capacity (32.3%) and high photothermal conversion efficiency (44.1%). Based on the resultant Au@Pt NPs, a cell membrane-coated photothermal nano-drug delivery system (i.e. the DOX/Au@Pt-M-NPs) was formulated by loading the Doxorubicin (DOX) onto the Au@Pt nanoparticles, which showed a stronger inhibitory effect on tumor cells. The use of the HeLa tumor cell membrane coating demonstrated significantly reinforcing effect on the absorption of the DOX/Au@Pt-M-NPs by tumor cells because of homologous targeting. The cytotoxicity and apoptosis rate of the DOX/Au@Pt-M-NPs group (73.4%) were significantly higher than that of the Au@Pt group (49%). In addition, the damage to major organs caused by the DOX/Au@Pt-M nanoparticle group was significantly lower than that by the DOX/Au@Pt nanoparticle group and the pure DOX group. Taken together, our work demonstrated that nanomedicine carriers camouflaged by tumor cell membranes combined with photothermal therapy and chemotherapy would have potential use in clinical tumor treatment.

仿生纳米给药系统的出现为癌症的临床治疗提供了一条可行的途径。贵金属纳米材料往往具有独特而引人入胜的理化性质、光学性质、电磁性质和催化性质，因此在生物医学领域有着广泛的应用。在这项工作中，通过将氯金酸（一种金前体）与氯铂酸钾（一种铂前体）以 1:1 的比例混合来合成多孔 Au@Pt 双金属纳米粒子。这些 Au@Pt NPs 表现出良好的催化性能、高载药量（32.3%）和高光热转换效率（44.1%）。基于所得到的 Au@Pt NPs，一种细胞膜包被的光热纳米药物递送系统（即 DOX/Au@Pt-M-NPs) 是通过将阿霉素 (DOX) 负载到 Au@Pt 纳米颗粒上而配制的，对肿瘤细胞显示出更强的抑制作用。由于同源靶向，HeLa 肿瘤细胞膜涂层的使用对肿瘤细胞对 DOX/Au@Pt-M-NPs 的吸收具有显着的增强作用。DOX/Au@Pt-M-NPs组的细胞毒性和凋亡率（73.4%）显着高于Au@Pt组（49%）。此外，DOX/Au@Pt-M纳米颗粒组对主要器官的损伤明显低于DOX/Au@Pt纳米颗粒组和纯DOX组。综合起来，