Most existing solutions for thiol detection require the addition of extra chemical agents to produce detection signals. However, the tedious operations in the sensing process are unfavorable for the real-time dynamic detection of thiol molecules. Herein, we present an all-organic graphene/poly(1,3,5-triethynylbenzene) (PTEB) composite for rapid and direct photoelectrochemical (PEC) analysis of multi-sulfhydryl compounds through specific thiol-yne click reaction. The non-covalent interfacial π-π interaction between the graphene and PTEB improves the optoelectronic properties of PTEB, which sensitizes the photocathode toward thiol detection with high sensitivity, broad linear range, and low detection limit. The theoretical calculation reveals that abundant 1,3-diyne linkages of PTEB are -SH sensitive active sites in PEC detection. Furthermore, a homemade sensing instrument has achieved real-time monitoring of thiol, suggesting its feasibility as an online sensor or a reaction monitor embedded in the industrial production line. Such progress holds promise for developing a diacetylene functionalized conjugated polymers-based -SH responsive platform for practical application in chemical production and quality control.

大多数现有的硫醇检测解决方案需要添加额外的化学试剂来产生检测信号。然而，传感过程中繁琐的操作不利于硫醇分子的实时动态检测。在此，我们提出了一种全有机石墨烯/聚（1,3,5-三乙炔基苯）（PTEB）复合材料，用于通过特定的硫醇-炔点击反应对多巯基化合物进行快速和直接的光电化学（PEC）分析。石墨烯和 PTEB 之间的非共价界面 π-π 相互作用改善了 PTEB 的光电特性，使光电阴极对硫醇检测敏感，具有高灵敏度、宽线性范围和低检测限。理论计算表明，PTEB 的大量 1,3-二炔键是 PEC 检测中的 -SH 敏感活性位点。此外，自制的传感仪器实现了硫醇的实时监测，表明其作为在线传感器或嵌入工业生产线的反应监测器的可行性。这些进展有望开发出基于丁二炔官能化共轭聚合物的-SH 响应平台，用于化学生产和质量控制的实际应用。