Scalable Yielding of Highly Stable Polyelectrolyte-Coated Copper Sulfide Nanoparticles by Flash Nanoprecipitation for Photothermal-Chemotherapeutics,Advanced Functional Materials

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Scalable Yielding of Highly Stable Polyelectrolyte-Coated Copper Sulfide Nanoparticles by Flash Nanoprecipitation for Photothermal-Chemotherapeutics
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2021-05-28 , DOI: 10.1002/adfm.202100452
Xianjing Jia ₁ , Yunfeng Yan ₂ , A. Basak Kayitmazer ₃ , Yongsheng Li _{1,

4} , Yisheng Xu _{4,

5}

Affiliation

Photothermal-chemotherapeutic nanoparticles (NPs) are attracting increasing attention and becoming more widely used for cancer therapy in the clinic due to their noninvasiveness, notable tissue penetration abilities, and low systemic adverse effects. However, functional ligands are conventionally modified onto photothermal NPs to well stabilize the inorganic particles suffering from complex chemical modifications, low productivity, and batch-to-batch inconsistencies, and thus significantly restricting their clinical applications. Herein, flash nanoprecipitation (FNP) is taken advantage of to afford rapid and uniform mixing for generating local supersaturated CuS clusters for small and highly stable CuS NPs effectively stabilized by polyacrylic acid through a continuous strategy. It greatly reduces the complexity for CuS NPs synthesis and functionalization in a facile intensified mixing process. These as-synthesized particles are high-drug loading, scalable, and most importantly, it is easy to control their sizes and charges through external conditions. Toxicity and tumor inhibition experiments confirm the high cell toxicity and good suppression of tumor growth under near-infrared irradiation indicating a promising prospect of FNP in the large-scale and continuous yielding of highly stable and high-performing photothermal-chemotherapeutic NPs for cancer therapy.

中文翻译：

用于光热-化学治疗的快速纳米沉淀法制备高度稳定的聚电解质涂覆的硫化铜纳米颗粒

光热化学治疗纳米粒子（NPs）由于其无创性、显着的组织穿透能力和低全身性副作用而引起越来越多的关注并在临床上更广泛地用于癌症治疗。然而，功能性配体通常被修饰到光热纳米颗粒上，以很好地稳定无机颗粒，这些颗粒具有复杂的化学修饰、低生产率和批次间不一致的问题，从而大大限制了它们的临床应用。在此，利用快速纳米沉淀（FNP）提供快速均匀的混合，以通过连续策略为聚丙烯酸有效稳定的小而高度稳定的 CuS NPs 产生局部过饱和的 CuS 簇。它在简单的强化混合过程中大大降低了 CuS NPs 合成和功能化的复杂性。这些合成的颗粒载药量高、可扩展，最重要的是，很容易通过外部条件控制它们的大小和电荷。毒性和肿瘤抑制实验证实了近红外辐射下的高细胞毒性和对肿瘤生长的良好抑制，表明 FNP 在大规模和连续生产用于癌症治疗的高度稳定和高性能的光热化学治疗 NP 方面具有广阔的前景。

更新日期：2021-05-28

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