Efficacy and Mechanisms of Oleuropein in Mitigating Diabetes and Diabetes Complications,Journal of Agricultural and Food Chemistry

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Efficacy and Mechanisms of Oleuropein in Mitigating Diabetes and Diabetes Complications
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2021-05-27 , DOI: 10.1021/acs.jafc.1c01404
Shujuan Zheng ₁ , Kunlun Huang ₁ , Tao Tong ₁

Affiliation

The global pandemic of diabetes and diabetes complications confers heavy pressure on public health. Novel antidiabetes strategies with negligible unwanted effects are urgently needed. Currently, the anti-hyperglycemic potential of plant-based functional ingredients has been explored to provide alternative strategies. As a kind of dietary bioactive compound, oleuropein has aroused the growing interest of researchers in diabetes and diabetes complications management. This review reveals the research progress of oleuropein in treating diabetes and diabetes complications and summarizes the molecular mechanisms involved in these beneficial effects of oleuropein. Oleuropein achieves amelioration of diabetes, the mechanisms of which include the modulation of insulin secretion, the repairment islet morphology, the activation of hepatic AMP-activated protein kinase singling, and the improvement of glucose tolerance and insulin resistance. Oleuropein also can relieve diabetes complications including diabetic nephropathy, diabetes cardiovascular complications, diabetic retinopathy, poor wound healing, diabetic neuropathy, and diabetic testicular dysfunction. Oleuropein reverses cell apoptosis, regenerates tissues, restores the histological organization, and decreases oxidative stress in treating diabetes complications. Taken together, oleuropein is a promising compound for diabetes and diabetes complications management and can be used as a nutraceutical to fight against these diseases.

中文翻译：

橄榄苦苷减轻糖尿病及糖尿病并发症的疗效及作用机制

糖尿病和糖尿病并发症的全球流行给公共卫生带来了沉重压力。迫切需要具有可忽略不计副作用的新型抗糖尿病策略。目前，已经探索了植物性功能成分的抗高血糖潜力，以提供替代策略。作为一种膳食生物活性化合物，橄榄苦苷已经引起了糖尿病和糖尿病并发症管理研究人员越来越多的兴趣。本文综述了橄榄苦苷在治疗糖尿病和糖尿病并发症方面的研究进展，并总结了橄榄苦苷这些有益作用的分子机制。橄榄苦苷达到改善糖尿病的作用，其机制包括调节胰岛素分泌、修复胰岛形态、肝AMP活化蛋白激酶单选的激活，以及葡萄糖耐量和胰岛素抵抗的改善。橄榄苦苷还可以缓解糖尿病并发症，包括糖尿病肾病、糖尿病心血管并发症、糖尿病视网膜病变、伤口愈合不良、糖尿病神经病变和糖尿病睾丸功能障碍。橄榄苦苷在治疗糖尿病并发症时逆转细胞凋亡、再生组织、恢复组织结构并减少氧化应激。总之，橄榄苦苷是一种用于糖尿病和糖尿病并发症管理的有前途的化合物，可用作对抗这些疾病的营养食品。糖尿病心血管并发症、糖尿病视网膜病变、伤口愈合不良、糖尿病神经病变和糖尿病睾丸功能障碍。橄榄苦苷在治疗糖尿病并发症时逆转细胞凋亡、再生组织、恢复组织结构并减少氧化应激。总之，橄榄苦苷是一种用于糖尿病和糖尿病并发症管理的有前途的化合物，可用作对抗这些疾病的营养食品。糖尿病心血管并发症、糖尿病视网膜病变、伤口愈合不良、糖尿病神经病变和糖尿病睾丸功能障碍。橄榄苦苷在治疗糖尿病并发症时逆转细胞凋亡、再生组织、恢复组织结构并减少氧化应激。总之，橄榄苦苷是一种用于糖尿病和糖尿病并发症管理的有前途的化合物，可用作对抗这些疾病的营养食品。

更新日期：2021-06-09

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