基于 pNIPAM 水凝胶的可充电给药系统用于姜黄素的局部释放,Journal of Applied Polymer Science

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基于 pNIPAM 水凝胶的可充电给药系统用于姜黄素的局部释放
Journal of Applied Polymer Science ( IF 2.7 ) Pub Date : 2021-05-24 , DOI: 10.1002/app.51167
Zahra Ayar ₁ , Mehdi Shafieian ₁ , Narges Mahmoodi ₂ , Omid Sabzevari _{3,

4} , Zahra Hassannejad ₅

Affiliation

本研究旨在开发基于聚（N-异丙基丙烯酰胺）（pNIPAM）水凝胶和合适溶剂的药物递送系统，以提高姜黄素的溶解度和局部释放。pNIPAM 水凝胶是通过自由基聚合合成的。研究了 pNIPAM 水凝胶作为可植入和可充电药物库的化学、机械和物理特性以及生物相容性。使用两种不同的溶剂在溶胀过程中将姜黄素加载到 pNIPAM 水凝胶中；甲醇，一种有机溶剂，和低分子量聚乙二醇 (PEG200)，一种聚合物溶剂。药物溶解度结果表明，使用PEG200比甲醇等常用有机溶剂更能提高姜黄素的溶解度。还，载药水凝胶的释放曲线表明，与甲醇 (8.765 ± 0.544 μg/ml) 相比，PEG200 在 1 周内对释放姜黄素的累积量 (33.163 ± 0.319 μg/ml) 具有更好的影响。根据我们的结果，加载姜黄素的水凝胶没有表现出任何细胞毒性，并且 pNIPAM/PEG 组合在 12 小时内表现出抗菌作用。因此，可以得出结论，pNIPAM 水凝胶与低分子量 PEG200 组合可用作有效的药物递送系统，以保持和提供姜黄素作为疏水性药物的持续释放。pNIPAM/PEG 组合在 12 小时内表现出抗菌作用。因此，可以得出结论，pNIPAM 水凝胶与低分子量 PEG200 组合可用作有效的药物递送系统，以保持和提供姜黄素作为疏水性药物的持续释放。pNIPAM/PEG 组合在 12 小时内表现出抗菌作用。因此，可以得出结论，pNIPAM 水凝胶与低分子量 PEG200 组合可用作有效的药物递送系统，以保持和提供姜黄素作为疏水性药物的持续释放。

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A rechargeable drug delivery system based on pNIPAM hydrogel for the local release of curcumin

This study was designed to develop a drug delivery system based on poly(N-isopropylacrylamide) (pNIPAM) hydrogel and a suitable solvent to enhance solubility and local release of curcumin. pNIPAM hydrogel was synthesized by radical polymerization. The chemical, mechanical and physical properties and biocompatibility of pNIPAM hydrogel were investigated as an implantable and rechargeable drug reservoir. Curcumin was loaded within pNIPAM hydrogel during swelling by using two different solvents; methanol, an organic solvent, and low molecular weight polyethylene glycol (PEG200), a polymeric solvent. The results of drug solubility showed that using PEG200 can increase curcumin solubility more than commonly used organic solvents such as methanol. Also, the release profile of drug-loaded hydrogels demonstrated that PEG200 has a superior effect on the cumulative amount of released curcumin (33.163 ± 0.319 μg/ml) compared to methanol (8.765 ± 0.544 μg/ml) during 1 week. Based on our results, curcumin-loaded hydrogels did not show any cytotoxicity, and pNIPAM/PEG combination represented an antibacterial effect within 12 hours. Accordingly, it can be concluded that pNIPAM hydrogel in combination with low molecular weight PEG200 could be used as an efficient drug delivery system to preserve and provide sustained release of curcumin as a hydrophobic drug.

更新日期：2021-07-16

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