In Vitro Effects of Stachyose on the Human Gut Microbiota,Starch

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In Vitro Effects of Stachyose on the Human Gut Microbiota
Starch ( IF 2.6 ) Pub Date : 2021-05-24 , DOI: 10.1002/star.202100029
Zhonglin Zhao ₁ , Wei Liu ₂ , Xionge Pi ₂

Affiliation

Gut microbiota plays an important role in human health. Stachyose, an oligosaccharide, modulates the gut microbiota composition in animals. However, the role of stachyose in promoting the proliferation of probiotics and whether it inhibits pathogenic micro-organisms in human gut microbiota has not been explored. Therefore, in this study, the effects of stachyose on the gut microbiota and its metabolites in humans are explored. Three concentrations of stachyose are used as the sole carbon source for in vitro fermentation. Results show that stachyose improves beta diversity and increases the concentration of short-chain fatty acid (SCFAs), mainly acetic acid and butyric acid. Stachyose is found to promote the relative abundance of Bifidobacteria, Faecalibacterium, Lactobacillus, and Prevotella genera in the gut microbiota. Besides, stachyose significantly reduces the relative abundance of Bacteroides and Escherichia-Shigella genera. The findings show that stachyose increases beneficial microbiota, therefore, it is a useful prebiotic which modulates the composition of the gut microbiota.

中文翻译：

水苏糖对人体肠道微生物群的体外作用

肠道微生物群在人类健康中起着重要作用。水苏糖是一种寡糖，可调节动物肠道微生物群的组成。然而，水苏糖在促进益生菌增殖中的作用以及它是否抑制人类肠道微生物群中的病原微生物尚未得到探索。因此，在本研究中，探讨了水苏糖对人体肠道微生物群及其代谢物的影响。三种浓度的水苏糖用作体外发酵的唯一碳源。结果表明，水苏糖改善了 β 多样性并增加了短链脂肪酸 (SCFA) 的浓度，主要是乙酸和丁酸。发现水苏糖促进双歧杆菌、粪杆菌、肠道微生物群中的乳酸杆菌和普氏菌属。此外，水苏糖显着降低了拟杆菌属和埃希氏菌-志贺氏菌属的相对丰度。研究结果表明，水苏糖增加了有益的微生物群，因此，它是一种有用的益生元，可调节肠道微生物群的组成。

更新日期：2021-07-02

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