Azobenzene is a well-known derivative of stimulus-responsive molecular switches and has shown superior performance as a functional material in biomedical applications. The results of multiple studies have led to the development of light/hypoxia-responsive azobenzene for biomedical use. In recent years, long-wavelength-responsive azobenzene has been developed. Matching the longer wavelength absorption and hypoxia-response characteristics of the azobenzene switch unit to the bio-optical window results in a large and effective stimulus response. In addition, azobenzene has been used as a hypoxia-sensitive connector via biological cleavage under appropriate stimulus conditions. This has resulted in on/off state switching of properties such as pharmacology and fluorescence activity. Herein, recent advances in the design and fabrication of azobenzene as a trigger in biomedicine are summarized.

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偶氮苯作为生物医学触发器的应用进展：分子设计和自发组装

偶氮苯是一种众所周知的刺激响应分子开关衍生物，在生物医学应用中作为功能材料显示出卓越的性能。多项研究的结果导致了用于生物医学用途的光/缺氧响应偶氮苯的开发。近年来，已开发出长波长响应的偶氮苯。将偶氮苯开关单元的较长波长吸收和缺氧响应特性与生物光学窗口相匹配，可产生大而有效的刺激响应。此外，偶氮苯已在适当的刺激条件下通过生物裂解用作缺氧敏感连接器。这导致了药理学和荧光活性等特性的开/关状态切换。在此处，