A short and scalable approach toward the total synthesis of schaftoside, a naturally occurring bioactive C-glycosylflavone, has been developed from readily available (±)-naringenin. The highlights of this work are double Lewis acid promoted O→C rearrangement to form C-glycoside, oxidative dehydrogenation to construct flavone ring, and easy operational process to make the target product in multigram-scale.

中文翻译：

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沙夫托苷的有效全合成

已经从现成的 (±)-柚皮素开发了一种短且可扩展的全合成 schaftoside 方法，一种天然存在的生物活性C-糖基黄酮。这项工作的亮点是双路易斯酸促进 O→C 重排形成 C-糖苷，氧化脱氢构建黄酮环，以及制备多克级目标产物的简单操作过程。