Tetracycline pollution is a growing global threat to aquatic and terrestrial biodiversity due to its unprecedented use in aquaculture, livestock, and human disease prevention. The influx of tetracycline may annihilate the microbial ecology structure in the environment and pose a severe threat to humans by disturbing the food chain. Although significant research data are available in the literature on various aspects of tetracycline, including detection techniques, degradation mechanisms, degradation products, and policy statements to curtail the issue, there is a scarcity of a report to compile the recent data in the literature for better analysis and comparison by the policymakers. To achieve this paucity in knowledge, the current study aims at collecting data on the available degradation strategies, mechanisms involved in biodegradable and non-biodegradable routes, the main factor affecting degradation strategies, compile novel detection techniques of tetracycline antibiotics in the environment, discuss antibiotic resistance genes and their potential role in degradation. Finally, limitations in the current bioremediation techniques and the future prospects are discussed with pointers for the decision-makers for a safer environment.