To investigate the bioaccumulation behavior of dodecamethylcyclohexasiloxane (D6, CAS number: 540-97-6) in fish, an OECD-305 style dietary bioaccumulation study of D6 in rainbow trout was conducted in the presence of non-metabolizable reference chemicals. The dietary uptake absorption efficiency of D6 was 14 (3 SE) % and lower than that of the reference chemicals which ranged between 22 (2 SE) to 60 (8 SE) %. The concentration of D6 in the body of the fish showed a rapid 40% drop during the first day of the depuration phase, followed by a slower decline during the remainder of the depuration period. The overall depuration rate constant of D6 was 0.016 (0.0026 SE) d⁻¹ and significantly greater than those of PCB153 and PCB209, which were not significantly different from zero. During the depuration phase, when fish body weight did not significantly change over time, depuration of D6 appears to be almost entirely due to biotransformation in the body of the fish. The biomagnification factor of D6 in rainbow trout was 0.38 (0.14 SE) kg-lipid kg-lipid⁻¹, indicating a lack of biomagnification. The bioconcentration factor (BCF) of D6 in Rainbow trout was estimated at 1909 (483 SE) L kg⁻¹ wet for natural waters of mostly oligotrophic lakes in Northern Canada with an average concentration of total organic carbon of 7.1 mg L⁻¹. Comparing the bioaccumulation profile of D6 to that of 238 similar profiles for 166 unique chemicals indicates that the bioaccumulation capacity of D6 is markedly less than that of many very hydrophobic organochlorines.

为了研究十二甲基环己硅氧烷（D6，CAS 编号：540-97-6）在鱼类中的生物积累行为，在存在不可代谢参考化学品的情况下，对虹鳟鱼中的 D6 进行了 OECD-305 样式的膳食生物积累研究。D6 的膳食吸收吸收效率为 14 (3 SE) %，低于参考化学品的 22 (2 SE) 至 60 (8 SE) %。在净化阶段的第一天，鱼体内 D6 的浓度显示出 40% 的快速下降，随后在净化期的剩余时间里下降较慢。D6 的总净化速率常数为 0.016 (0.0026 SE) d ^-1并且显着大于 PCB153 和 PCB209，它们与零没有显着差异。在净化阶段，当鱼的体重没有随时间发生显着变化时，D6 的净化似乎几乎完全是由于鱼体内的生物转化。D6 在虹鳟鱼中的生物放大系数为 0.38 (0.14 SE) kg-lipid kg-lipid ^-1，表明缺乏生物放大作用。虹鳟鱼中 D6 的生物浓缩因子 (BCF) 估计为 1909 (483 SE) L kg ^{− 1}湿，对于加拿大北部大部分贫营养湖泊的天然水域，总有机碳的平均浓度为 7.1 mg L ^{− 1}. 将 D6 的生物积累曲线与 166 种独特化学品的 238 种类似曲线的生物积累曲线进行比较，表明 D6 的生物积累能力明显低于许多疏水性极强的有机氯的生物积累能力。