The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling exert essential regulatory function in microbial-and onco-immunology through the induction of cytokines, primarily type I interferons. Recently, the aberrant and deranged signaling of the cGAS–STING axis is closely implicated in multiple sterile inflammatory diseases, including heart failure, myocardial infarction, cardiac hypertrophy, nonalcoholic fatty liver diseases, aortic aneurysm and dissection, obesity, etc. This is because of the massive loads of damage-associated molecular patterns (mitochondrial DNA, DNA in extracellular vesicles) liberated from recurrent injury to metabolic cellular organelles and tissues, which are sensed by the pathway. Also, the cGAS–STING pathway crosstalk with essential intracellular homeostasis processes like apoptosis, autophagy, and regulate cellular metabolism. Targeting derailed STING signaling has become necessary for chronic inflammatory diseases. Meanwhile, excessive type I interferons signaling impact on cardiovascular and metabolic health remain entirely elusive. In this review, we summarize the intimate connection between the cGAS–STING pathway and cardiovascular and metabolic disorders. We also discuss some potential small molecule inhibitors for the pathway. This review provides insight to stimulate interest in and support future research into understanding this signaling axis in cardiovascular and metabolic tissues and diseases.

环状 GMP-AMP 合酶 (cGAS) - 干扰素基因刺激物 (STING) 信号传导通过诱导细胞因子（主要是 I 型干扰素）在微生物和肿瘤免疫学中发挥重要的调节功能。最近，cGAS-STING 轴的异常和紊乱信号与多种无菌性炎症疾病密切相关，包括心力衰竭、心肌梗塞、心脏肥大、非酒精性脂肪肝疾病、主动脉瘤和夹层、肥胖等。这是因为大量与损伤相关的分子模式（线粒体DNA，细胞外囊泡中的DNA）从代谢细胞器和组织的反复损伤中释放出来，这些是由通路感知的。此外，cGAS-STING 通路与细胞内基本稳态过程如细胞凋亡、自噬、并调节细胞代谢。针对脱轨的 STING 信号传导已成为慢性炎症性疾病的必要条件。同时，过量的 I 型干扰素信号对心血管和代谢健康的影响仍然完全难以捉摸。在这篇综述中，我们总结了 cGAS-STING 通路与心血管和代谢疾病之间的密切联系。我们还讨论了该途径的一些潜在小分子抑制剂。这篇综述提供了激发兴趣和支持未来研究以了解心血管和代谢组织和疾病中的这一信号轴的见解。过量的 I 型干扰素信号对心血管和代谢健康的影响仍然完全难以捉摸。在这篇综述中，我们总结了 cGAS-STING 通路与心血管和代谢疾病之间的密切联系。我们还讨论了该途径的一些潜在小分子抑制剂。这篇综述提供了激发兴趣和支持未来研究以了解心血管和代谢组织和疾病中的这一信号轴的见解。过量的 I 型干扰素信号对心血管和代谢健康的影响仍然完全难以捉摸。在这篇综述中，我们总结了 cGAS-STING 通路与心血管和代谢疾病之间的密切联系。我们还讨论了该途径的一些潜在小分子抑制剂。这篇综述提供了激发兴趣和支持未来研究以了解心血管和代谢组织和疾病中的这一信号轴的见解。