Seriously compromised function of some organs can only be restored by transplantation. Due to the shortage of human donors, the need to find another source of organs is of primary importance. Decellularized scaffolds of non-human origin are being studied as highly potential biomaterials for tissue engineering. Their biological nature and thus the ability to provide a naturally-derived environment for human cells to adhere and grow highlights their great advantage in comparison to synthetic scaffolds. Nevertheless, since every biomaterial implanted in the body generates immune reaction, studying the interaction of the scaffold with the surrounding tissues is necessary. This review aims to summarize current knowledge on the immunogenicity of semi-xenografts involved in transplantation. Moreover, positive aspects of the interaction between xenogeneic scaffold and human cells are discussed, focusing on specific roles of proteins associated with extracellular matrix in cell adhesion and signalling.

一些器官的功能严重受损只能通过移植来恢复。由于人类捐赠者的短缺，寻找另一种器官来源的需求至关重要。非人类来源的脱细胞支架正在研究中，作为用于组织工程的极有潜力的生物材料。与合成支架相比，它们的生物学特性以及因此为人类细胞提供粘附和生长的自然来源环境的能力凸显了它们的巨大优势。然而，由于植入体内的每种生物材料都会产生免疫反应，因此有必要研究支架与周围组织的相互作用。这篇综述旨在总结有关移植中半异种移植物的免疫原性的当前知识。而且，