Obesity is a complex syndrome and is recognized as the ultimate pathway of many chronic diseases. Studies using Akkermansia muciniphila supplementation strategy have proved to be effective for the prevention and treatment of obesity and other metabolic disorders. Although there are studies that support the protective effect of this strategy, the effects on the prevention of obesity on humans are not clear yet and need more investigation. The aim of this study is to investigate the effect of A. muciniphila administration on modulating obesity. This systematic review was generated from articles published within the last 10 years. All articles were in English and included animal subjects. The review relied on the search engines Google Scholar, Pub Med, Web of Science and Medline using the following keywords: A. muciniphila, next-generation probiotic, new-generation probiotic, obesity, fat mass, body fat and lipid profile. The search has revealed 804 articles with relevant key words. After the exclusion of irrelevant articles, 10 studies were selected based on the criteria. These studies were randomized controlled trials that have shown that A. muciniphila modulates obesity by regulating metabolism and energy hemostasis and improving insulin sensitivity and glucose hemostasis. In addition, studies showed this microorganism enhances low grade inflammation by different mechanisms.

中文翻译：

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Akkermansia muciniphila，调节肥胖症的新一代有益菌群：系统评价

肥胖是一种复杂的综合症，被认为是许多慢性疾病的最终途径。研究证明，使用Akkermansia muciniphila补充策略可有效预防和治疗肥胖症和其他代谢性疾病。尽管有研究支持该策略的保护作用，但对于预防肥胖症对人类的影响尚不明确，需要进一步研究。这项研究的目的是调查黏液曲霉的影响调节肥胖的管理。该系统评价来自最近十年中发表的文章。所有文章均为英文，包括动物主题。该评论使用以下关键字依赖于搜索引擎Google Scholar，Pub Med，Web of Science和Medline：粘液曲霉，下一代益生菌，新一代益生菌，肥胖症，脂肪量，体脂和脂质状况。搜索发现804条带有相关关键词的文章。在排除无关文章之后，根据标准选择了10项研究。这些研究是随机对照试验，这些试验表明黏液曲霉通过调节代谢和能量止血并改善胰岛素敏感性和葡萄糖止血来调节肥胖。此外，研究表明，这种微生物通过不同的机制增强了低度炎症。