In this work, we firstly developed a new method for the synthesis of hierarchical mesoporous hollow Ce-MOF nanosphere templated by diblock copolymer. The hierarchical hollow mesoporous Ce-MOF nanosphere as the oxidase mimic shows highly catalytic chromogenic activity toward 3,3,5,5-tetramethylbenzidine (TMB) without the presence of H₂O₂, and it can be used as a substitute for peroxidase mimics and H₂O₂ system in the colorimetric reaction. Herein, we provide a new highly sensitive and selective colorimetric method for the detection of Ascorbic acid (AA). At the optimal pH (3.5), temperature (the room temperature), time (5 min) and TMB concentration (280 μM), the limit of detection (LOD) was 0.03 µM, the range of the detection was 8 to 56 µM.

在这项工作中，我们首先开发了一种以二嵌段共聚物为模板合成分级介孔中空Ce-MOF纳米球的新方法。分级的中空介孔Ce-MOF纳米球作为氧化酶模拟物，在不存在H ₂ O ₂的情况下，对3,3,5,5-四甲基联苯胺（TMB）具有很高的催化显色活性，可以用作过氧化物酶模拟物的替代物和H ₂ O ₂比色反应中的体系。在此，我们提供了一种新的高灵敏度和选择性比色法来检测抗坏血酸（AA）。在最佳pH（3.5），温度（室温），时间（5分钟）和TMB浓度（280μM）下，检测限（LOD）为0.03 µM，检测范围为8至56 µM。