Trinucleotide Cap Analogue Bearing a Locked Nucleic Acid Moiety: Synthesis, mRNA Modification, and Translation for Therapeutic Applications,Organic Letters

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Trinucleotide Cap Analogue Bearing a Locked Nucleic Acid Moiety: Synthesis, mRNA Modification, and Translation for Therapeutic Applications
Organic Letters ( IF 4.9 ) Pub Date : 2021-05-19 , DOI: 10.1021/acs.orglett.1c01037
Annamalai Senthilvelan ₁ , Tyson Vonderfecht ₂ , Muthian Shanmugasundaram ₁ , Indra Pal ₃ , Jason Potter ₂ , Anilkumar R Kore ₁

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The synthesis of a new trinucleotide cap analogue containing a locked nucleic acid (LNA) moiety such as m^7(LNA)G(5′)ppp(5′)A_mpG and its molecular biology applications are described. The most appealing feature is that this new cap analogue outperforms the standard trinucleotide cap m⁷G(5′)ppp(5′)A_mpG and the anti-reverse cap analogue m₂^7,3′-OG(5′)ppp(5′)G by a factor of 5 in terms of translational efficiency.

中文翻译：

带有锁定核酸部分的三核苷酸帽类似物：用于治疗应用的合成、mRNA 修饰和翻译

描述了含有锁核酸 (LNA) 部分的新三核苷酸帽类似物的合成，例如 m ^7(LNA) G(5')ppp(5')A _m pG 及其分子生物学应用。最吸引人的特点是，这种新的帽类似物优于标准三核苷酸帽米⁷ G（5'）PPP（5'）甲_米PG和防反转帽类似物米₂^{7,3'- ø} G（5'） ppp(5')G 的翻译效率提高了 5 倍。

更新日期：2021-06-04

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