4-(1,3-Thiazol-2-yl)morpholine derivatives have been identified as potent and selective inhibitors of phosphoinositide 3-kinase. The SAR data of selected examples are presented and the in vivo profiling of compound 18 is shown to demonstrate the utility of this class of compounds in xenograft models of tumor growth.

中文翻译：

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4-（1,3-噻唑-2-基）吗啉衍生物作为磷酸肌醇3-激酶的抑制剂。

已经确定了4-（1,3-噻唑-2-基）吗啉衍生物是磷酸肌醇3-激酶的有效和选择性抑制剂。给出了所选实施例的SAR数据，并显示了化合物18的体内概况分析，以证明这类化合物在肿瘤生长的异种移植模型中的实用性。