The global concern for depletion of fossil fuel and greenhouse gas emission demands a rigorous research on development of sustainable alternate fuels and important chemicals from the renewable second generation lignocellulosic biomass in the last decade. In this review, upgradation of pyrolysis bio-oil, derived from lignocellulosic biomass, using alkylation as an effective C–C coupling reaction between its phenolics and C₁–C₄ oxygenate constituents is discussed. There is a considerable loss of light oxygenates in existing bio-oil upgrading technologies employing hydrodeoxygenation process and this loss can be overcome by using them as alkylates in the alkylation reaction of the aromatic oxygenates, namely, phenolics, also present in it, before the subsequent hydrodeoxygenation step, which will avoid carbon loss and improve the yields of the valorization products. In this context, a review of research advances in the area of catalytic alkylation of phenolic compounds with different alkylating agents (C₁–C₄ alcohol/olefins) and with special attention to m-cresol alkylation with iso-propanol is discussed. This review classifies the reported literature into thermodynamic, catalytic activity, mechanistic, and kinetic analyses to give a clear picture of the research data on this reaction and an outlook for the process scale-up. The review of such reactions using this classification has not been reported so far.

在全球范围内，对化石燃料和温室气体枯竭的关注要求在过去十年中，对可再生替代燃料和第二代可再生木质纤维素生物质中重要化学物质的开发进行严格的研究。在这篇综述中，利用烷基化作为酚类与C ₁ -C ₄之间的有效CC偶联反应，可对源自木质纤维素生物质的热解生物油进行升级。含氧化合物的组成进行了讨论。在采用加氢脱氧工艺的现有生物油提质技术中，轻质含氧化合物的损失很大，可以通过在随后的芳族含氧化合物的烷基化反应中将它们用作烷基化反应物（也存在于其中的酚）中的烷基化物来克服这种损失。加氢脱氧步骤，可避免碳损失并提高增值产品的收率。在这种情况下，对酚类化合物与不同烷基化剂（C ₁ -C ₄醇/烯烃）的催化烷基化领域的研究进展进行了综述，并特别关注了间甲苯酚与异氰酸酯的烷基化反应。讨论了丙醇。这篇综述对报道的文献进行了热力学，催化活性，机理和动力学分析，以清晰地了解有关该反应的研究数据，并展望了该方法的规模化发展前景。迄今为止，尚未报道使用这种分类对此类反应进行综述。