Chemodynamic therapy (CDT) is a novel therapeutic modality that employs Fenton or Fenton-like reactions to destroy cancer cells via the disproportionation of intratumoral hydrogen peroxide (H₂O₂) to the highly toxic hydroxyl radical (•OH) without external energy input. However, the poor effectiveness of CDT has limited its clinical application. Therefore, over the past few years, various strategies have been explored to enhance the efficiency of CDT. In this review, we have provided an overview of the strategies used to improve CDT performance, including the increased production, accelerated generation, and enhanced efficacy of hydroxyl radicals. Furthermore, the challenges and perspectives of emerging and potential CDT techniques are also discussed; this review is expected to stimulate the development of non-invasive and efficacious CDT techniques.

化学动力疗法（CDT）是一种新颖的治疗方法，它利用Fenton或类Fenton反应通过肿瘤内过氧化氢（H ₂ O _2）的歧化破坏癌细胞。）转化为剧毒的羟基（•OH），而无需外部能量输入。但是，CDT效果差，限制了其临床应用。因此，在过去的几年中，已经探索了各种策略来提高CDT的效率。在这篇综述中，我们提供了用于改善CDT性能的策略的概述，包括提高产量，加速产生和增强羟基自由基的功效。此外，还讨论了新兴的和潜在的CDT技术的挑战和前景；预期该评论将刺激无创和有效的CDT技术的发展。