A convenient synthetic route to 2-heteroaryl-3-hydroxybenzo[b]thiophene derivatives via K₂CO₃-promoted multicomponent cyclization between o-halogenated benzaldehyde, 2-methylquinolines and sulfur powder has been demonstrated. This reaction is performed smoothly under simple conditions to give the corresponding products in moderate to good yields. The resultant 3-hydroxybenzo[b]thiophenes have been proved to be versatile building blocks in a range of transition-metal-catalyzed cross-coupling reactions.

中文翻译：

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无过渡金属条件下2-杂芳基-3-羟基苯并[b]-噻吩的三组分合成

已经证明了通过K ₂ CO ₃促进的邻卤代苯甲醛、2-甲基喹啉和硫粉之间的多组分环化来合成2-杂芳基-3-羟基苯并[ b ]噻吩衍生物的便捷合成路线。该反应在简单的条件下顺利进行，以中等至良好的收率得到相应的产物。所得的 3-羟基苯并[ b ]噻吩已被证明是一系列过渡金属催化的交叉偶联反应中的通用构件。