Tangutidines A–C, Three Amphoteric Diterpene Alkaloids from Aconitum tanguticum,Natural Products and Bioprospecting

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Tangutidines A–C, Three Amphoteric Diterpene Alkaloids from Aconitum tanguticum
Natural Products and Bioprospecting ( IF 4.8 ) Pub Date : 2021-05-12 , DOI: 10.1007/s13659-021-00310-3
Hao-Yi Li _{1,

2} , Bing-Chao Yan ₁ , Li-Xin Wei ₃ , Han-Dong Sun ₁ , Pema-Tenzin Puno ₁

Affiliation

Three new diterpene alkaloids, tangutidines A–C (1–3), and four known alkaloids (4–7) were isolated from the whole plant of Aconitum tanguticum, from which amphoteric diterpene alkaloids (1–3) were obtained for the first time. The structures of 1–3 were elucidated by detailed interpretation of spectroscopic data, including MS and NMR data. All of them were evaluated for their cytotoxic activities.