Metal–organic framework (MOF) membranes hold great promise in energy-efficient chemical separations. The outstanding challenges of the microstructural design stem from (1) thinning of membranes to immensely reduce the mass-transfer resistance (for high permeances); (2) tuning of orientation to optimize the selective transport of gas molecules, and (3) reinforcement of intercrystalline structure to subside leakage through defective gaps (for high selectivity). Here, we propose the ZIF-L membrane that is completely confined into the voids of the alumina support through an interfacial assembly process, producing an appealing membrane-interlocked-support (MIS) composite architecture that meets the requirements of the microstructural design of MOF membranes. Consequently, the membranes show average H₂ permeances of above 4000 GPU and H₂/CO₂ separation factor (SF) of above 200, representing record-high separation performances of ZIF-L membranes and falling into the industrial target zone (H₂ permeance > 1000 GPU and H₂/CO₂ SF > 60). Furthermore, the ZIF-L membrane possessing the MIS composite architecture that is established with alumina particles as scaffolds shows mechanical stability, scraped repeatedly by a piece of silicon rubber causing no selectivity loss.

金属有机骨架 (MOF) 膜在节能化学分离方面具有广阔前景。微观结构设计的突出挑战源于（1）减薄膜以极大地降低传质阻力（用于高渗透）；(2) 调整方向以优化气体分子的选择性传输，以及 (3) 加强晶间结构以减少通过缺陷间隙的泄漏（以获得高选择性）。在这里，我们提出了 ZIF-L 膜，它通过界面组装过程完全限制在氧化铝支撑的空隙中，产生了一种吸引人的膜互锁支撑 (MIS) 复合结构，满足 MOF 膜微观结构设计的要求. 因此，膜显示平均 H ₂4000 GPU以上的渗透率和200以上的H ₂ /CO ₂分离因子（SF），代表了ZIF-L膜的历史最高分离性能并进入工业目标区域（H ₂渗透率> 1000 GPU和H ₂ /CO ₂平方英尺 > 60)。此外，具有 MIS 复合结构的 ZIF-L 膜以氧化铝颗粒作为支架建立，显示出机械稳定性，被一块硅橡胶反复刮擦不会造成选择性损失。