Cobalt-Catalyzed Umpolung Alkylation of Imines To Generate α-Branched Aliphatic Amines,Organic Letters

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Cobalt-Catalyzed Umpolung Alkylation of Imines To Generate α-Branched Aliphatic Amines
Organic Letters ( IF 4.9 ) Pub Date : 2021-05-11 , DOI: 10.1021/acs.orglett.1c00835
Li-Qiang Wan ₁ , Jin-Ge Cao ₁ , Dawen Niu ₁ , Xia Zhang ₁

Affiliation

Here we report a general and mild approach to prepare α-branched aliphatic amines from imines. This method capitalizes on a cobalt-catalyzed umpolung alkylation of imines, employs easily available reaction partners, and demonstrates a broad substrate scope. Mechanistic studies suggest this transformation occurs by a radical pathway.

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