Borate bioactive glass (BBG) stimulates angiogenesis and promotes cell growth. However, controlling the degradation rate of BBG and maintaining the critical concentration of bioactive ions suitable for cell promotion and differentiation remain great challenges in soft tissue repair. In this study, a novel approach was proposed to produce nanosized CO₃²⁻-containing hydroxyapatite (HCA)-coated BBG (nano-HCA@BG). Unlike the previously reported hard-to-degrade hydroxyapatite (HA) coating after static soaking treatment of BBG, the nano-HCA@BG, obtained by dynamically immersing the BBG powder in a flowing buffer, had a porous structure and was surface-coated with a layer of amorphous HCA, which improved the biocompatibility and retained the biodegradability of BBG. The effects of nano-HCA@BG were evaluated and compared with those of powdered BBG at the cellular and animal levels. The formation of the HCA-coated nanoporous architecture significantly improves biocompatibility, promotes cell growth and proliferation, and is beneficial for wound healing in rodent skin defects.

硼酸盐生物活性玻璃 (BBG) 可刺激血管生成并促进细胞生长。然而，控制BBG的降解速率和维持适合细胞促进和分化的生物活性离子的临界浓度仍然是软组织修复的巨大挑战。在这项研究中，提出了一种生产纳米级 CO ₃ ²⁻的新方法。-含羟基磷灰石 (HCA) 涂层的 BBG（纳米-HCA@BG）。与先前报道的 BBG 静态浸泡处理后难以降解的羟基磷灰石 (HA) 涂层不同，通过将 BBG 粉末动态浸入流动缓冲液中获得的纳米 HCA@BG 具有多孔结构，表面涂有一层无定形HCA，提高了生物相容性并保留了BBG的生物降解性。在细胞和动物水平上评估了纳米 HCA@BG 的效果，并与粉状 BBG 的效果进行了比较。HCA 涂层纳米多孔结构的形成显着提高了生物相容性，促进细胞生长和增殖，有利于啮齿动物皮肤缺损的伤口愈合。