从基底外侧杏仁核到前扣带皮层的投射有助于巩固长期戒断记忆,Addiction Biology

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从基底外侧杏仁核到前扣带皮层的投射有助于巩固长期戒断记忆
Addiction Biology ( IF 3.1 ) Pub Date : 2021-05-11 , DOI: 10.1111/adb.13048
Da Shao _{1,

2} , Zixuan Cao ₁ , Yali Fu ₁ , Hao Yang ₁ , Pengyu Gao ₁ , Ping Zheng ₁ , Bin Lai ₁

Affiliation

早期记忆转移到大脑皮层形成长期记忆的过程称为记忆巩固，而基底外侧杏仁核（BLA）是参与这一过程的重要脑区。尽管 BLA 和多个大脑区域之间的功能连接对于巩固戒断记忆至关重要，但从 BLA 到前扣带皮层 (ACC) 的投射是否参与了戒断记忆的形成或巩固仍不清楚。在本文中，我们使用化学遗传方法在组合吗啡戒断和条件性位置厌恶（CPA）动物模型中专门标记 BLA-ACC 投影。我们发现（1）调节过程中 BLA-ACC 投射的抑制对早期戒断记忆的形成没有影响；(2) BLA-ACC 投射的抑制对早期或长期戒断记忆的恢复没有影响；(3) 早期戒断记忆形成后对 BLA-ACC 投射的持续抑制可以抑制长期戒断记忆的形成并降低 ACC 中 Arc 蛋白的表达。这些结果表明，早期戒断记忆形成后 BLA-ACC 投射的持续激活通过增加 ACC 神经元的可塑性来促进长期戒断记忆的形成。(3) 早期戒断记忆形成后对 BLA-ACC 投射的持续抑制可以抑制长期戒断记忆的形成并降低 ACC 中 Arc 蛋白的表达。这些结果表明，早期戒断记忆形成后 BLA-ACC 投射的持续激活通过增加 ACC 神经元的可塑性促进了长期戒断记忆的形成。(3) 早期戒断记忆形成后对 BLA-ACC 投射的持续抑制可以抑制长期戒断记忆的形成并降低 ACC 中 Arc 蛋白的表达。这些结果表明，早期戒断记忆形成后 BLA-ACC 投射的持续激活通过增加 ACC 神经元的可塑性促进了长期戒断记忆的形成。

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Projection from the basolateral amygdala to the anterior cingulate cortex facilitates the consolidation of long-term withdrawal memory

The process through which early memories are transferred to the cerebral cortex to form long-term memories is referred to as memory consolidation, and the basolateral amygdala (BLA) is an important brain region involved in this process. Although functional connections between the BLA and multiple brain regions are critical for the consolidation of withdrawal memory, whether the projection from the BLA to the anterior cingulate cortex (ACC) is involved in the formation or consolidation of withdrawal memory remains unclear. In this paper, we used a chemical genetic method to specifically label the BLA–ACC projection in a combined morphine withdrawal and conditioned place aversion (CPA) animal model. We found that (1) the inhibition of the BLA–ACC projection during conditioning had no effects on the formation of early withdrawal memory; (2) the inhibition of the BLA–ACC projection had no effects on the retrieval of either early or long-term withdrawal memory; and (3) the persistent inhibition of the BLA–ACC projection after early withdrawal memory formation could inhibit the formation of long-term withdrawal memory and decrease Arc protein expression in the ACC. These results suggested that the persistent activation of the BLA–ACC projection after the formation of early withdrawal memory facilitates the formation of long-term withdrawal memory by increasing the plasticity of ACC neurons.

更新日期：2021-05-11

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