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Near-infrared inorganic nanomaterial-based nanosystems for photothermal therapy
Nanoscale ( IF 5.8 ) Pub Date : 2021-4-14 , DOI: 10.1039/d1nr00323b Yufei Wang 1, 2, 3, 4, 5 , Hong-Min Meng 1, 2, 3, 4, 5 , Zhaohui Li 1, 2, 3, 4, 5
Nanoscale ( IF 5.8 ) Pub Date : 2021-4-14 , DOI: 10.1039/d1nr00323b Yufei Wang 1, 2, 3, 4, 5 , Hong-Min Meng 1, 2, 3, 4, 5 , Zhaohui Li 1, 2, 3, 4, 5
Affiliation
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The development of robust materials for treating diseases through non-invasive photothermal therapy (PTT) has attracted increasing attention in recent years. Among various types of nanomaterials, inorganic nanomaterials with strong absorption in the near-infrared (NIR) window can be employed as high-efficiency photothermal agents to treat cancer and bacterial infections. In addition, inorganic nanomaterials can be easily combined with other drugs or chemical reagents to construct multifunctional nanomaterials to cascade stimulation responses, enhance therapeutic effects, and perform precise medical treatments. In this review, focusing on the latest developments of inorganic nanomaterials in photothermal therapy, we firstly introduced the light-to-heat conversion mechanism of inorganic nanomaterials. Secondly, we summarized the application of common inorganic nanomaterials, such as metallic nanoparticles, transition metal oxide nanoparticles and two dimensional (2D) nanosheets. In addition, the strategy of developing multifunctional nano-platforms with excellent biocompatibility as well as good targeted capability was also expounded. Finally, challenges and new perspectives for designing effective inorganic nanomaterial-based nanosystems for photothermal assisted therapy were also discussed.
中文翻译：
用于光热疗法的基于近红外无机纳米材料的纳米系统
近年来，通过无创光热疗法（PTT）治疗疾病的坚固材料的开发吸引了越来越多的关注。在各种类型的纳米材料中，在近红外（NIR）窗口中具有强吸收性的无机纳米材料可以用作治疗癌症和细菌感染的高效光热剂。另外，无机纳米材料可以容易地与其他药物或化学试剂结合以构建多功能纳米材料，以级联刺激反应，增强治疗效果并进行精确的医学治疗。本文以光热疗法中无机纳米材料的最新发展为重点，首先介绍了无机纳米材料的光热转换机理。第二，我们总结了常见的无机纳米材料的应用，例如金属纳米颗粒，过渡金属氧化物纳米颗粒和二维（2D）纳米片。此外，还阐述了开发具有优异生物相容性和良好靶向能力的多功能纳米平台的策略。最后，还讨论了为光热辅助疗法设计有效的基于无机纳米材料的纳米系统的挑战和新观点。
更新日期：2021-05-11
中文翻译：
用于光热疗法的基于近红外无机纳米材料的纳米系统
近年来，通过无创光热疗法（PTT）治疗疾病的坚固材料的开发吸引了越来越多的关注。在各种类型的纳米材料中，在近红外（NIR）窗口中具有强吸收性的无机纳米材料可以用作治疗癌症和细菌感染的高效光热剂。另外，无机纳米材料可以容易地与其他药物或化学试剂结合以构建多功能纳米材料，以级联刺激反应，增强治疗效果并进行精确的医学治疗。本文以光热疗法中无机纳米材料的最新发展为重点，首先介绍了无机纳米材料的光热转换机理。第二，我们总结了常见的无机纳米材料的应用，例如金属纳米颗粒，过渡金属氧化物纳米颗粒和二维（2D）纳米片。此外，还阐述了开发具有优异生物相容性和良好靶向能力的多功能纳米平台的策略。最后，还讨论了为光热辅助疗法设计有效的基于无机纳米材料的纳米系统的挑战和新观点。
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