石莼提取物通过氧化/抗氧化途径和炎症生物标志物对重金属混合物诱导的心血管的改善作用。,Environmental Science and Pollution Research

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石莼提取物通过氧化/抗氧化途径和炎症生物标志物对重金属混合物诱导的心血管的改善作用。
Environmental Science and Pollution Research Pub Date : 2021-01-26 , DOI: 10.1007/s11356-020-11994-4
Asmaa Nabil-Adam ₁ , Mohamed A Shreadah ₁

Affiliation

目前的研究调查了石莼多酚提取物 (ULPE) 的一般治疗和疗效，特别是多酚化合物对重金属混合物 (HME) 的治疗和疗效。重金属背后的毒性是由于重金属污染或通过受污染的食物（蔬菜、水和鱼）给药引起的氧化应激。重金属毒性在不同的心血管疾病中起主要作用。本研究的目的是检查 ULPE 通过氧化/抗氧化和炎症途径对重金属混合物诱导的心血管疾病的保护作用。六十只雄性大鼠（Sprague-Dawley）被分配到六组。I组为对照组，II组为诱导组，皮下注射7天0。25 毫克/100 克体重/天的重金属混合物（等浓度的 Ni、Cd、Co 和 Hg 氯化物以及醋酸铅），III 组接受（ip）剂量 30mg 的 ULPE，持续 15 天，IV 组作为保护组用ULPE预处理15天作为保护剂量，然后用重金属混合物处理，V组作为保护标准组用维生素C（VitC）（50mg/Kg）预处理，然后用重金属处理-混合物，VI组作为用VitC(50mg/Kg)处理的标准组。心脏内的主要病理变化显示重金属混合物给药后的心脏炎症。与用 ULPE 处理的受保护组（IV 组）相比，保护组（II 组）显示出抗氧化剂和抗炎生物标志物的显着增加。心血管生物标志物（肌钙蛋白 T、CRP 和 BNP）在诱导组中表现出相似的态度升高，而在保护组和 VitC 组中则显着降低。ULPE 的抗氧化和抗炎活性是其较高的多酚含量以及海洋次生代谢物的结果，通过定性和定量分析证实了这一点。根据目前的结果，我们得出结论，ULPE 具有心血管保护剂，这是由于高含量的不同生物活性次级代谢产物具有抗氧化、清除自由基和抗炎活性。显示了 ULPE 对重金属混合物具有心脏保护作用的机制。ULPE 的抗氧化和抗炎活性是其较高的多酚含量以及海洋次生代谢物的结果，通过定性和定量分析证实了这一点。根据目前的结果，我们得出结论，ULPE 具有心血管保护剂，这是由于高含量的不同生物活性次级代谢产物具有抗氧化、清除自由基和抗炎活性。显示了 ULPE 对重金属混合物具有心脏保护作用的机制。ULPE 的抗氧化和抗炎活性是其较高的多酚含量以及海洋次生代谢物的结果，通过定性和定量分析证实了这一点。根据目前的结果，我们得出结论，ULPE 具有心血管保护剂，这是由于高含量的不同生物活性次级代谢产物具有抗氧化、清除自由基和抗炎活性。显示了 ULPE 对重金属混合物具有心脏保护作用的机制。我们得出结论，ULPE 具有心血管保护剂，这是由于高含量的不同生物活性次级代谢产物具有抗氧化、清除自由基和抗炎活性。显示了 ULPE 对重金属混合物具有心脏保护作用的机制。我们得出结论，ULPE 具有心血管保护剂，这是由于高含量的不同生物活性次级代谢产物具有抗氧化、清除自由基和抗炎活性。显示了 ULPE 对重金属混合物具有心脏保护作用的机制。

"点击查看英文标题和摘要"

Ameliorative role of Ulva extract against heavy metal mixture-induced cardiovascular through oxidative/antioxidant pathways and inflammatory biomarkers.

The current study investigates the therapeutic and curative effect of Ulva lactuca polyphenolic extract (ULPE) in general and particularly polyphenolics compounds against heavy metal mixture (HME). The toxicity behind heavy metal is due to oxidative stress resulted from heavy metals pollution or administration through contaminated food (vegetables, water, and fish). Heavy metal toxicity plays a major role in different cardiovascular diseases. The objective of this study is aimed to examine the protective effect of ULPE against heavy metal mixture induced cardiovascular diseases through oxidative/antioxidant and inflammatory pathways. Sixty male rats (Sprague-Dawley) were assigned to six groups. Group I served as the control, group II served as the induced group receiving subcutaneously for 7 days 0.25 mg/100 gm body weight/day heavy metal mixtures (Equal concentration of Ni, Cd, Co and Hg chloride, and Pb acetate), group III received (i.p.) ULPE of dose 30 mg for 15 days, group IV served as the protected group pretreated with ULPE for 15 days as a protection dose, and then treated with the heavy metal-mixture, group V served as protected standard group pretreated with vitamin C (VitC ) (50 mg/Kg) and then treated with the heavy metal-mixture, and group VI served as standard group treated with VitC (50 mg/Kg). The main pathological changes within the heart revealed heart inflammation after heavy-metal mixtures administrations. On contrast to the protected group treated with ULPE (group IV), the protection group (group II) showed a significant increase in the antioxidant as well as anti-inflammatory biomarker. The cardiovascular biomarkers (Troponin T, CRP, and BNP) showed similar attitude elevations in induction group and decreased greatly in protection and VitC group. The antioxidant and the anti-inflammatory activities of ULPE are a consequence of their higher polyphenolic contents as well as marine secondary metabolites which are confirmed using qualitative and quantitative analysis. From the current result, we concluded that ULPE possesses a cardiovascular protective agent as a result of highly contents of different bioactive secondary metabolites which have antioxidant as well as free-radical scavenging and anti-inflammatory activates. Showed the mechanism of ULPE as cardioprotective against heavy metal mixture.

更新日期：2021-01-26

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