甲基丙烯酸二甲氨基乙酯和甲基丙烯酸甲酯的抗菌两亲性共聚物，可控制生物膜的粘附性，以用于防污应用。,Polymers

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甲基丙烯酸二甲氨基乙酯和甲基丙烯酸甲酯的抗菌两亲性共聚物，可控制生物膜的粘附性，以用于防污应用。
Polymers ( IF 4.7 ) Pub Date : 2021-01-09 , DOI: 10.3390/polym13020216
Shehla Mushtaq ₁ , Nasir M Ahmad ₂ , Azhar Mahmood ₁ , Mudassir Iqbal ₁

Affiliation

两亲共聚物由于有效抑制细菌生长，因此被认为是重要的生物材料，并被用作抗菌剂。在当前的研究中，通过改变PDI值为1.65的亲水性单体2-二甲基氨基乙基甲基丙烯酸酯（DMAEMA）和疏水性单体甲基丙烯酸甲酯（MMA）的浓度，通过自由基聚合反应合成了P（DMAEMA-co-MMA）的两亲共聚物。 1.93。DMAEMA单体通过具有抗菌性能的三元胺优化了共聚物P（DMAEMA-co-MMA），以控制生物膜的附着力。通过圆盘扩散法阐明了合成共聚物对革兰氏阳性金黄色葡萄球菌（ATCC 6538）和革兰氏阴性大肠杆菌（ATCC 8739）的抗菌活性，并测定了抑菌圈。所需的PDM1共聚物组合物显示出良好的抑制区域，即大肠杆菌和金黄色葡萄球菌分别为19±0.33 mm和20±0.33 mm。通过六孔板法测试，PDM1和PDM2已显示出对细菌生物膜粘附的显着控制。细菌生物膜形成的SEM研究表明，这些共聚物的行为与阳离子杀生物剂相似。这些组成即。PDM1和PDM2在生物反应器，传感器，手术设备和药物输送装置的开发中可能有用。细菌生物膜形成的SEM研究表明，这些共聚物的行为与阳离子杀生物剂相似。这些组成即。PDM1和PDM2在生物反应器，传感器，手术设备和药物输送装置的开发中可能有用。细菌生物膜形成的SEM研究表明，这些共聚物的行为与阳离子杀生物剂相似。这些组成即。PDM1和PDM2在生物反应器，传感器，手术设备和药物输送装置的开发中可能有用。

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Antibacterial Amphiphilic Copolymers of Dimethylamino Ethyl Methacrylate and Methyl Methacrylate to Control Biofilm Adhesion for Antifouling Applications.

Amphiphilic copolymers are recognized as important biomaterials and used as antibacterial agents due to their effective inhibition of bacterial growth. In current study, the amphiphilic copolymers of P(DMAEMA-co-MMA) were synthesized using free radical polymerization by varying the concentrations of hydrophilic monomer 2-dimethylamino ethylmethacrylate (DMAEMA) and hydrophobic monomer methyl methacrylate (MMA) having PDI value of 1.65-1.93. The DMAEMA monomer, through ternary amine with antibacterial property optimized copolymers, P(DMAEMA-co-MMA), compositions to control biofilm adhesion. Antibacterial activity of synthesized copolymers was elucidated against Gram-positive Staphylococcus aureus (ATCC 6538) and Gram-negative Escherchia coli (ATCC 8739) by disk diffusion method, and zones of inhibition were measured. The desired composition that was PDM1 copolymer had shown good zones of inhibition i.e., 19 ± 0.33 mm and 20 ± 0.33 mm for E. coli and S. aureus respectively. The PDM1 and PDM2 have exhibited significant control over bacterial biofilm adhesion as tested by six well plate method. SEM study of bacterial biofilm formation has illustrated that these copolymers act in a similar fashion like cationic biocide. These compositions viz. PDM1 and PDM2, may be useful in development of bioreactors, sensors, surgical equipment and drug delivery devices.

更新日期：2021-01-09

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