Pyrene is a typical high molecular weight polycyclic aromatic hydrocarbon (HMW-PAH), and its biodegradation has been widely studied. Different microorganisms, including fungi, bacteria and cyanobacteria, have been shown to degrade pyrene as a source of carbon and energy. Bacteria are important pyrene degraders in different environments. To date, different bacterial phylotypes and their pyrene degradation pathways have been studied. This review will provide the latest information to deepen our understanding of pyrene degradation by bacteria, especially in PAHs contaminated environments. The principal biomarkers of pyrene metabolism (nidA/B, pah, and phd genes), bacterial community with pyrene degradation ability and their biodegradation mechanisms were reviewed. Additionally, a potential novel pyrene catabolic pathway of Roseobacter clade bacteria was discussed. We suggest that future studies should explore more application of multi-omics approaches and bioinformatics data to identify novel PAHs catabolic enzymes and pathways in other bacteria, rather than limiting research focus in functional genetic indices.

is是一种典型的高分子量多环芳烃（HMW-PAH），其生物降解作用已得到广泛研究。研究表明，包括真菌，细菌和蓝细菌在内的各种微生物可降解pyr，将其作为碳和能量的来源。细菌是不同环境中重要的pyr降解剂。迄今为止，已经研究了不同的细菌系统型及其their降解途径。这篇综述将提供最新信息，以加深我们对细菌降解especially的理解，尤其是在多环芳烃污染的环境中。metabolism代谢的主要生物标志物（nidA / B，pah和phd基因），具有pyr降解能力的细菌群落及其生物降解机理进行了综述。另外，讨论了玫瑰红杆菌进化枝细菌的潜在的新型pyr分解代谢途径。我们建议，未来的研究应探索多组学方法和生物信息学数据的更多应用，以识别其他细菌中的新型PAHs分解代谢酶和途径，而不是限制功能基因指标的研究重点。