Background: Despite significant advancement in oncology research, cancer still poses one of the leading causes of mortality worldwide. The increased incidences of cancer may be attributed to the limited efficacy and disastrous side effects of conventional therapies like chemotherapy, radiotherapy and surgery. Azole containing medicinal agents are known for plethora of medicinal properties, including anticancer potential.

Objective: In this review, we highlighted azole containing natural products with anticancer potential from marine sources.

Methods: A comprehensive literature search was performed for writing the review. Updated views about various marine sponges, cyanobacteria, tunicates and microalgae producing azole nucleus containing secondary metabolites with anticancer potential have been discussed.

Results: The present article describes the structural, chemical, and biological features of azoles containing natural agents from marine sources with promising anti-cancer potential. Additionally, current challenges and future perspectives of azoles in cancer prevention and treatment are also discussed.

Conclusion: This review might encourage scientific community to explore marine sources for developing novel and potent azole containing anti-cancer agents with better safety profile.

背景：尽管肿瘤学研究取得了重大进展，但癌症仍然是全球死亡的主要原因之一。癌症发病率的增加可能归因于传统疗法（如化学疗法、放射疗法和手术）的疗效有限和灾难性的副作用。含有唑类的药物具有多种药用特性，包括抗癌潜力。

目的：在这篇综述中，我们重点介绍了来自海洋的具有抗癌潜力的含有唑类的天然产品。

方法：为撰写评论进行了全面的文献检索。已经讨论了关于各种海绵、蓝细菌、被囊类动物和微藻产生唑核的最新观点，这些含有具有抗癌潜力的次级代谢物。

结果：本文描述了含有来自海洋的天然药物的唑类的结构、化学和生物学特征，具有良好的抗癌潜力。此外，还讨论了唑类在癌症预防和治疗中的当前挑战和未来前景。

结论：本综述可能会鼓励科学界探索海洋资源，以开发具有更好安全性的新型强效唑类抗癌剂。