人表皮生长因子研究进展,Sheng wu gong cheng xue bao = Chinese journal of biotechnology

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人表皮生长因子研究进展
Sheng wu gong cheng xue bao = Chinese journal of biotechnology Pub Date : 2020-12-25 , DOI: 10.13345/j.cjb.200209
Meiyu Wu ₁ , Jinghua Ruan ₁ , Boxiong Zhong ₁

Affiliation

人表皮生长因子（hEGF）是激活表皮生长因子受体的生长因子家族的典型成员。它是由人体的多个组织和器官合成和分泌的，通过与受体结合并激活一系列信号通路来调节细胞的增殖，分化和迁移。近年来，关于hEGF的研究已经扩展到其在人类生理和病理学中的作用，特别是在组织再生和伤口愈合中的作用。本文综述了hEGF的研究进展，简要介绍了hEGF的基因和蛋白结构，特征，机制和生物学作用，重点介绍了其在胃肠道溃疡愈合，皮肤创面修复和肿瘤病理学中的作用和影响。

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[Progress in human epidermal growth factor research].

Human epidermal growth factor (hEGF) is a typical member of the growth factor family that activates epidermal growth factor receptors. It is synthesized and secreted by multiple tissues and organs of the human body, regulating the cell proliferation, differentiation and migration via binding to receptors and activating a series of signaling pathways. In recent years, the research on hEGF has been extended to its role in human physiology and pathology, especially in tissue regeneration and wound healing. This paper reviews the research progress of hEGF, briefly describes its gene and protein structure and characteristics, mechanisms and biological effects, with the emphasis on the roles and influences in the healing of gastrointestinal ulcers, skin wound repair and tumor pathology. 人表皮生长因子是激活表皮生长因子受体的生长因子家族的典型成员，由人体的多个组织器官合成与分泌，通过结合受体激活一系列信号途径，调控细胞的增殖、分化和迁移等。近年来，有关人表皮生长因子的研究已扩展到其在人类生理和病理作用的领域，尤其在组织再生和伤口愈合方面成为研究热点。文中综述了人表皮生长因子的研究进展，简要描述了其基因和蛋白的结构与特点、作用机制与生物学效应，重点介绍该生长因子在胃肠溃疡愈合、皮肤伤口修复和肿瘤病理过程中的作用与影响，从而为相关研究提供辅助信息。.

更新日期：2020-12-25

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