Current Pharmaceutical Design ( IF 2.6 ) Pub Date : 2021-05-01 , DOI: 10.2174/1381612826666201102101428 Elham Ramazani 1 , Maryam Akaberi 2 , Seyed Ahmad Emami 3 , Zahra Tayarani-Najaran 1
Background: Gamma-oryzanol (γ-oryzanol) is one of the rice bran oil (RBO) compounds, known as a principal food source throughout the world. In recent numerous experimental studies, γ-oryzanol has been revealed to have several useful pharmacological properties, such as anti-oxidant, anti-inflammatory, anti-cancer, anti-diabetic, ameliorating unpleasant menopausal symptoms, cholesterol-lowering, improving plasma lipid pattern, etc.
Methods: In this study, we reviewed the scientific literature published up until 2020, which has evaluated the biological and pharmacological activity of gamma-oryzanol. This review summarizes the published data found in PubMed, Science Direct, and Scopus.
Results and Conclusion: The present review attempts to summarize the most related articles about the pharmacological and therapeutic potential from recent studies on γ-oryzanol to gain insights into design further studies to achieve new evidence that confirm the observed effects.
中文翻译:
γ-谷维素的生物和药理作用:分子机制的最新回顾
背景:γ-谷维素 (γ-oryzanol) 是米糠油 (RBO) 化合物之一,是世界范围内的主要食物来源。在最近的大量实验研究中,γ-谷维素已被揭示具有多种有用的药理特性,例如抗氧化、抗炎、抗癌、抗糖尿病、改善令人不快的更年期症状、降低胆固醇、改善血脂模式, 等等。
方法:在这项研究中,我们回顾了截至 2020 年发表的科学文献,这些文献评估了 γ-谷维素的生物学和药理活性。本综述总结了在 PubMed、Science Direct 和 Scopus 中发现的已发表数据。
结果和结论:本综述试图总结最近关于 γ-谷维素的研究中有关药理和治疗潜力的最相关文章,以深入了解设计进一步的研究,以获取证实观察到的效果的新证据。