Role of Semisulcospira gottschei extract as medicinal food on reflux esophagitis in rats,Food Science & Nutrition

当前位置： X-MOL 学术 › Food Sci. Nutr. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Role of Semisulcospira gottschei extract as medicinal food on reflux esophagitis in rats
Food Science & Nutrition ( IF 3.5 ) Pub Date : 2021-05-06 , DOI: 10.1002/fsn3.2270
Hyeon Hwa Nam ₁ , Sungyu Yang ₁ , Hyo Seon Kim ₁ , Min Jee Kim ₁ , Joong Sun Kim ₁ , Ji Hye Lee _{1,

2}

Affiliation

Gastroesophageal reflux disease (GERD) is a globally prevalent disease and results from a reflux of gastric contents into the esophagus. Existing synthetic drug-based treatments for GERD have various drawbacks including refractory symptoms, relapse, or resistance due to long-term use or may result in mucosal degeneration, polyps, and osteoporosis. Semisulcospira gottschei (SE), a freshwater snail, has been generally consumed as a food source due to its excellent flavor and nutritional value in Korea and considered to have therapeutic properties for various diseases including dyspepsia, stomachache, and hepatic diseases. The present study aims to investigate whether Semisulcospira gottschei extract (SGE) has a protective effect on reflux esophagitis-induced rat models. The anti-inflammatory effects of SGE were evaluated via NO production in LPS-induced Raw 264.7 macrophage. And the protection effects of SGE were analyzed by assessing the amelioration of mucosal damage and expression of inflammation-associated proteins in reflux esophagitis (RE) rats. Our results indicate that SGE significantly suppressed NO production in LPS-induced raw 264.7 cells without any cytotoxicity. We observed mucosal lesions and histological changes in the esophagus of RE control rats. However, SGE treatment markedly ameliorated mucosal lesion ratio indicated through histological changes. SGE administration suppressed the expression of proteins related to inflammation, such as p-NF-κB, p-IκBα, COX-2, and TNF-α, in esophageal tissue. Moreover, SGE elevated the expression of claudin-5, which is a tight junction protein, involved in barrier function of epithelium and endothelium. The results suggest that SGE is useful as a medicinal food in esophagitis and may be helpful in developing effective treatment protocols for GERD.

中文翻译：

戈氏半硫螺旋菌提取物作为药用食品对大鼠反流性食管炎的作用

胃食管反流病（GERD）是一种全球流行的疾病，是由胃内容物反流到食管引起的。现有的基于合成药物的 GERD 治疗方法存在多种缺点，包括难治性症状、复发或因长期使用而产生耐药性，或可能导致粘膜变性、息肉和骨质疏松。 Semisulcospira Gottschei (SE) 是一种淡水蜗牛，在韩国因其优异的风味和营养价值而被普遍作为食物来源食用，并被认为具有治疗消化不良、胃痛和肝脏疾病等多种疾病的功效。本研究旨在探讨戈特氏半沟螺提取物（SGE）是否对反流性食管炎诱导的大鼠模型具有保护作用。通过 LPS 诱导的 Raw 264.7 巨噬细胞中 NO 的产生来评估 SGE 的抗炎作用。通过评估反流性食管炎（RE）大鼠粘膜损伤的改善和炎症相关蛋白的表达来分析SGE的保护作用。我们的结果表明，SGE 显着抑制 LPS 诱导的原始 264.7 细胞中 NO 的产生，且没有任何细胞毒性。我们观察了 RE 对照大鼠食管的粘膜病变和组织学变化。然而，组织学变化表明，SGE 治疗显着改善了粘膜病变率。 SGE 给药抑制了食管组织中与炎症相关的蛋白质的表达，如 p-NF-κB、p-IκBα、COX-2 和 TNF-α。此外，SGE 还提高了claudin-5 的表达，claudin-5 是一种紧密连接蛋白，参与上皮和内皮的屏障功能。结果表明，SGE 可作为治疗食管炎的药用食品，并可能有助于制定有效的 GERD 治疗方案。

更新日期：2021-06-11

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南