Currently, the expanding recreational use of synthetic cannabinoids (SCBs) threatens public health. SCBs produce psychoactive effects similar to those of tetrahydrocannabinol, the main component of cannabis, and additionally induce unexpected pharmacological side effects. SCBs are falsely advertised as legal and safe, but in reality, SCB abuse has been reported to cause acute intoxication and addictive disorders. However, because of the lack of scientific evidence to elucidate their dangerous pharmacological effects, SCBs are weakly regulated and continue to circulate in illegal drug markets. In the present study, the intravenous self-administration (IVSA) paradigm was used to evaluate the abuse potential of three SCBs (AM-1248, CB-13, and PB-22) in rats. All three SCBs maintained IVSA with a large number of infusions and active lever presses, demonstrating their reinforcing effects. The increase of active lever presses was particularly significant during the early IVSA sessions, indicating the reinforcementenhancing effects of the SCBs (AM-1248 and CB-13). The number of inactive lever presses was significantly higher in the SCB groups (AM-1248 and CB-13) than that in the vehicle group, indicating their impulsive effects. In summary, these results demonstrated that SCBs have distinct pharmacological properties and abuse potential.

中文翻译：

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合成大麻素的滥用潜力：AM-1248，CB-13和PB-22。

当前，合成大麻素（SCB）在娱乐上的广泛使用威胁着公共健康。SCB产生与大麻主要成分四氢大麻酚相似的精神活性，并另外引起意想不到的药理副作用。虚假宣传SCB是合法和安全的，但实际上，据报滥用SCB会引起急性中毒和成瘾性疾病。但是，由于缺乏科学的证据来阐明其危险的药理作用，SCBs的监管较弱，并继续在非法药品市场中流通。在本研究中，静脉内自我给药（IVSA）范式用于评估三种SCB（AM-1248，CB-13和PB-22）在大鼠中的滥用潜力。所有三个SCB都通过大量输液和主动杠杆按压来维持IVSA，展示它们的增强作用。在IVSA早期会议期间，主动杠杆压力机的增加尤其显着，这表明SCB（AM-1248和CB-13）具有增强作用。SCB组（AM-1248和CB-13）的无效按动杆数明显高于车辆组，表明了它们的冲动效果。总之，这些结果表明SCB具有独特的药理特性和滥用潜力。表明它们的冲动效果。总之，这些结果表明SCB具有独特的药理特性和滥用潜力。表明它们的冲动效果。总之，这些结果表明SCB具有独特的药理特性和滥用潜力。