<br>基于触摸的无压力皮质醇传感,Advanced Materials

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基于触摸的无压力皮质醇传感
Advanced Materials ( IF 27.4 ) Pub Date : 2021-03-30 , DOI: 10.1002/adma.202008465
Wanxin Tang _{1,

2} , Lu Yin ₁ , Juliane R Sempionatto ₁ , Jong-Min Moon ₁ , Hazhir Teymourian ₁ , Joseph Wang ₁

Affiliation

跟踪皮质醇水平的波动对于了解身体对压力刺激的内分泌反应非常重要。传统的皮质醇传感依赖于集中式实验室设置，而可穿戴皮质醇传感器仅限于缓慢且复杂的分析。这里描述了一种基于触摸的非侵入性分子印迹聚合物（MIP）电化学传感器，用于快速、简单、可靠、无压力地检测汗液皮质醇。该传感器通过与皮质醇印迹电聚合聚吡咯涂层的高选择性结合，轻松测量指尖汗液皮质醇。 MIP 网络嵌入了普鲁士蓝氧化还原探针，可提供结合事件的直接电信号，以实现灵敏的无标记安培检测。采用高渗透性的排汗多孔水凝胶，无需任何帮助即可方便、快速地收集瞬时分泌的指尖汗液。与以前的方法相比，通过消除时间滞后，这种快速（3.5 分钟）指尖检测能够捕获皮质醇水平的急剧变化。这些优势通过在短期冷加压测试和全天昼夜节律中跟踪皮质醇反应以及金标准免疫测定验证来证明。还描述了一种可拉伸表皮 MIP 传感器，用于直接跟踪运动引起的汗液中的皮质醇。基于快速触摸的皮质醇传感器为定量压力管理提供了一种有吸引力的、易于使用的、无压力的途径。

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Touch‐Based Stressless Cortisol Sensing

Tracking fluctuations of the cortisol level is important in understanding the body's endocrine response to stress stimuli. Traditional cortisol sensing relies on centralized laboratory settings, while wearable cortisol sensors are limited to slow and complex assays. Here, a touch‐based non‐invasive molecularly imprinted polymer (MIP) electrochemical sensor for rapid, simple, and reliable stress‐free detection of sweat cortisol is described. The sensor readily measures fingertip sweat cortisol via highly selective binding to the cortisol‐imprinted electropolymerized polypyrrole coating. The MIP network is embedded with Prussian blue redox probes that offer direct electrical signaling of the binding event to realize sensitive label‐free amperometric detection. Using a highly permeable sweat‐wicking porous hydrogel, instantaneously secreted fingertip sweat can be conveniently and rapidly collected without any assistance. By eliminating time lags, such rapid (3.5 min) fingertip assay enables the capture of sharp variations in cortisol levels, compared to previous methods. Such advantages are demonstrated by tracking cortisol response in short cold‐pressor tests and throughout day‐long circadian rhythm, along with gold‐standard immunoassay validation. A stretchable epidermal MIP sensor is also described for directly tracking cortisol in exercise‐induced sweat. The rapid touch‐based cortisol sensor offers an attractive, accessible, stressless avenue for quantitative stress management.

更新日期：2021-05-05

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