3D Printing Unique Nanoclay-Incorporated Double-Network Hydrogels for Construction of Complex Tissue Engineering Scaffolds,Advanced Healthcare Materials

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3D Printing Unique Nanoclay-Incorporated Double-Network Hydrogels for Construction of Complex Tissue Engineering Scaffolds
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2021-05-05 , DOI: 10.1002/adhm.202100036
Zhongwei Guo _{1,

2} , Lina Dong ₂ , Jingjing Xia ₃ , Shengli Mi ₁ , Wei Sun _{1,

2,

3,

4}

Affiliation

The development of new biomaterial inks with good structural formability and mechanical strength is critical to the fabrication of 3D tissue engineering scaffolds. For extrusion-based 3D printing, the resulting 3D constructs are essentially a sequential assembly of 1D filaments into 3D constructs. Inspired by this process, this paper reports the recent study on 3D printing of nanoclay-incorporated double-network (NIDN) hydrogels for the fabrication of 1D filaments and 3D constructs without extra assistance of support bath. The frequently used “house-of-cards” architectures formed by nanoclay are disintegrated in the NIDN hydrogels. However, nanoclay can act as physical crosslinkers to interact with polymer chains of methacrylated hyaluronic acid (HAMA) and alginate (Alg), which endows the hydrogel precursors with good structural formability. Various straight filaments, spring-like loops, and complex 3D constructs with high shape-fidelity and good mechanical strength are fabricated successfully. In addition, the NIDN hydrogel system can easily be transformed into a new type of magnetic responsive hydrogel used for 3D printing. The NIDN hydrogels also supported the growth of bone marrow mesenchymal stem cells and displayed potential calvarial defect repair functions.

中文翻译：

用于构建复杂组织工程支架的 3D 打印独特的纳米粘土掺入双网络水凝胶

开发具有良好结构成型性和机械强度的新型生物材料墨水对于 3D 组织工程支架的制造至关重要。对于基于挤出的 3D 打印，生成的 3D 构造本质上是将 1D 细丝按顺序组装成 3D 构造。受此过程的启发，本文报告了最近关于纳米粘土掺入双网络 (NIDN) 水凝胶的 3D 打印研究，用于制造 1D 细丝和 3D 结构，而无需额外的支持浴。由纳米粘土形成的常用“纸牌屋”结构在 NIDN 水凝胶中分解。然而，纳米粘土可以作为物理交联剂与甲基丙烯酸化透明质酸 (HAMA) 和海藻酸盐 (Alg) 的聚合物链相互作用，从而赋予水凝胶前体良好的结构成型性。成功地制造了各种直丝、弹簧状环和具有高形状保真度和良好机械强度的复杂 3D 结构。此外，NIDN水凝胶系统可以很容易地转化为一种用于3D打印的新型磁响应水凝胶。NIDN 水凝胶还支持骨髓间充质干细胞的生长并显示出潜在的颅骨缺损修复功能。

更新日期：2021-06-09

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