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A mitochondrial-targeted ratiometric probe for detecting intracellular H2S with high photostability
Chinese Chemical Letters ( IF 9.4 ) Pub Date : 2020-12-29 , DOI: 10.1016/j.cclet.2020.12.044
Dandan Bu , Yuying Wang , Na Wu , Wei Feng , Donghui Wei , Zhanxian Li , Mingming Yu

Based on 4-bromo-1,8-naphthalic anhydride, one novel ratiometric fluorescence H2S-probe (IDNA) was designed and synthesized. Further studies indicate that IDNA can sensitively recognize H2S (detection limit of 7 μmol/L) with good selectivity and anti-interference ability. In addition, IDNA has satisfactory photostability in HeLa cells, ability of mitochondrial co-localization, and can be utilized in fluorescence imaging of H2S.



中文翻译:

用于检测高光稳定性细胞内H 2 S的线粒体靶向比例探针

基于4-溴-1,8-萘酐,设计合成了一种新型的比例荧光H 2 S探针(IDNA)。进一步的研究表明,IDNA可以灵敏地识别H 2 S(检测限为7μmol/ L),具有良好的选择性和抗干扰能力。此外,IDNA在HeLa细胞中具有令人满意的光稳定性,线粒体共定位能力,可用于H 2 S的荧光成像。

更新日期:2020-12-29
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