Iron-Catalyzed Three-Component Cyanoalkylsulfonylation of 2,3-Allenoic Acids, Sulfur Dioxide, and Cycloketone Oxime Esters: Access to Cyanoalkylsulfonylated Butenolides,Advanced Synthesis & Catalysis

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Iron-Catalyzed Three-Component Cyanoalkylsulfonylation of 2,3-Allenoic Acids, Sulfur Dioxide, and Cycloketone Oxime Esters: Access to Cyanoalkylsulfonylated Butenolides
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2021-05-04 , DOI: 10.1002/adsc.202100463
Xiangyun Zheng ₁ , Tianshuo Zhong ₁ , Xiao Yi ₁ , Qitao Shen ₁ , Chuanliu Yin ₁ , Lei Zhang ₁ , Jian Zhou ₁ , Junyu Chen ₁ , Chuanming Yu ₁

Affiliation

An iron-catalyzed three-component cyanoalkylsulfonylation of 2,3-allenoic acids, K₂S₂O₅, and the ring-opening of cyclobutanone oxime esters is described. The radical tandem cyclization route allows access to diverse cyanoalkylsulfonylated butenolides in moderate to good yields under mild conditions. Moreover, the products are further converted, offering the corresponding derivatives.

中文翻译：

铁催化的 2,3-烯丙酸、二氧化硫和环酮肟酯的三组分氰烷基磺酰化：获得氰烷基磺酰化丁烯内酯

描述了铁催化的 2,3-丙二烯酸、K ₂ S ₂ O _{5 的}三组分氰基烷基磺酰化和环丁酮肟酯的开环。自由基串联环化路线允许在温和条件下以中等至良好的产率获得各种氰基烷基磺酰化丁烯内酯。此外，产品进一步转换，提供相应的衍生产品。

更新日期：2021-07-04

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