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4-(Di-/Trifluoromethyl)-2-heterabicyclo[2.1.1]hexanes: Advanced Fluorinated Phenyl Isosteres and Proline analogues
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2021-05-05 , DOI: 10.1002/ejoc.202100414 Anton A. Homon 1 , Oleksandr V. Hryshchuk 2 , Olha V. Mykhailenko 2 , Bohdan V. Vashchenko 2 , Kostiantyn P. Melnykov 2 , Oleg Michurin 2 , Constantin G. Daniliuk 3 , Igor I. Gerus 4 , Volodymyr O. Kovtunenko 5 , Kondratov Ivan 6 , Oleksandr O. Grygorenko 5
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2021-05-05 , DOI: 10.1002/ejoc.202100414 Anton A. Homon 1 , Oleksandr V. Hryshchuk 2 , Olha V. Mykhailenko 2 , Bohdan V. Vashchenko 2 , Kostiantyn P. Melnykov 2 , Oleg Michurin 2 , Constantin G. Daniliuk 3 , Igor I. Gerus 4 , Volodymyr O. Kovtunenko 5 , Kondratov Ivan 6 , Oleksandr O. Grygorenko 5
Affiliation
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A robust gram-scale synthesis, physico-chemical characterization, and lead-likeness assessment of novel 4-di/trifluoromethyl-2-heterabicyclo[2.1.1]hexane building blocks as fluorinated 2,4-methanoproline analogues and phenyl isosteres are disclosed.
中文翻译：
4-(二-/三氟甲基)-2-杂双环[2.1.1]己烷：高级氟化苯基等排体和脯氨酸类似物
公开了新型 4-二/三氟甲基-2-杂双环 [2.1.1] 己烷结构单元作为氟化 2,4-甲脯氨酸类似物和苯基等排体的稳健的克级合成、物理化学表征和铅相似性评估。
更新日期：2021-05-05
中文翻译：
4-(二-/三氟甲基)-2-杂双环[2.1.1]己烷：高级氟化苯基等排体和脯氨酸类似物
公开了新型 4-二/三氟甲基-2-杂双环 [2.1.1] 己烷结构单元作为氟化 2,4-甲脯氨酸类似物和苯基等排体的稳健的克级合成、物理化学表征和铅相似性评估。
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