Inconsistent results have been reported for the effects of the mitogen-activating extracellular kinase (MEK) inhibitor α-[amino(4-aminophenyl)thio]methylene-2-(trifluoromethyl)benzeneacetonitrile (SL 327) on ethanol-induced conditioned place preference (EtOH-CPP). Since such inconsistencies may be due to the configurational composition of administered SL 327, the interconvertibility of the geometric isomers of this class of compounds has been investigated. This study provides conditions for determination of configurational composition of this class of compounds by HPLC and by ¹H NMR and reports details of configurational equilibria as a function of medium and time in solution along with solubility data for SL 327 in aqueous DMSO. The results suggest that the apparently inconsistent results reported for CPP-EtOH may be due to the administration of suspension vs. solutions, as well as to different configurational compositions of SL 327.

关于促分裂原激活细胞外激酶 (MEK) 抑制剂 α-[氨基(4-氨基苯基)硫代]亚甲基-2-(三氟甲基)苯乙腈 (SL 327) 对乙醇诱导的条件性位置偏好的影响的报道不一致的结果。乙醇-CPP)。由于这种不一致可能是由于施用的 SL 327 的构型组成，因此已经研究了这类化合物的几何异构体的相互转化性。本研究为用高效液相色谱法和¹H NMR 并报告了作为溶液中介质和时间函数的构型平衡的详细信息，以及 SL 327 在 DMSO 水溶液中的溶解度数据。结果表明，CPP-EtOH 报告的明显不一致的结果可能是由于施用了悬浮液与s。解决方案，以及 SL 327 的不同配置组成。