Inconsistent results have been reported for the effects of the mitogen-activating extracellular kinase (MEK) inhibitor α-[amino(4-aminophenyl)thio]methylene-2-(trifluoromethyl)benzeneacetonitrile (SL 327) on ethanol-induced conditioned place preference (EtOH-CPP). Since such inconsistencies may be due to the configurational composition of administered SL 327, the interconvertibility of the geometric isomers of this class of compounds has been investigated. This study provides conditions for determination of configurational composition of this class of compounds by HPLC and by ¹H NMR and reports details of configurational equilibria as a function of medium and time in solution along with solubility data for SL 327 in aqueous DMSO. The results suggest that the apparently inconsistent results reported for CPP-EtOH may be due to the administration of suspension vs. solutions, as well as to different configurational compositions of SL 327.

关于丝裂原激活细胞外激酶 (MEK) 抑制剂 α-[氨基(4-氨基苯基)硫基]亚甲基-2-(三氟甲基)苯乙腈 (SL 327) 对乙醇诱导的条件性位置偏好的影响，结果不一致。乙醇-CPP）。由于这种不一致可能是由于所施用的 SL 327 的构型组成造成的，因此已经研究了此类化合物的几何异构体的相互转换性。本研究提供了通过 HPLC 和¹ H NMR 测定此类化合物的构型组成的条件，并报告了作为溶液中介质和时间的函数的构型平衡的详细信息以及 SL 327 在含水 DMSO 中的溶解度数据。结果表明，CPP-EtOH 报道的明显不一致的结果可能是由于悬浮液与s 的给药所致。解决方案，以及 SL 327 的不同配置组合物。